Alexandre G. Lellouch

Department of Plastic Surgery

Harvard University

Alexandre G. Lellouch

I am currently a Board-certified plastic surgeon in Paris and co-investigator / Lecturer at MGH/ Harvard. I have extensive experience with reconstructive microsurgery. I am working with Pr. Laurent Lantieri, Hospital George Pompidou, Paris and Dr Curtis Cetrulo, Massachusetts General Hospital, Boston. The hand and face transplantation as clinical options in the treatment of severely injured and disfigured patients led to an interest in the field of reconstructive transplantation. Vascularized Composite allograft (VCA) has emerged in recent years as the most promising treatment option for many patients afflicted with soft tissue defects that cannot be satisfactorily reconstructed using contemporary techniques. Moreover, VCA has overtaken tissue engineering by becoming a clinically viable option. Unfortunately, the prognostic in the long term is compromised due to the ineluctable development of chronic rejection and the absence of treatment available. To overcome this issue, I had the pleasure to collaborate with Drs. Uygun (Korkut and Basak), Dr Benichou and Dr. Cetrulo to work on the decellularization technology, perfusion machine and induction of tolerance protocols. We have concluded that VCA will produce the biggest breakthrough, provided the associated immunological concerns can be adequately addressed.

Publications

Partial Heterotopic Hindlimb Transplantation Model in Rats

1Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, 2Vascularized Composite Allotransplantation Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, 3Shriners Hospital for Children, 4Service de Chirurgie Plastique, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris (APHP), Université de Paris

JoVE 62586

 Immunology and Infection