Christiane Bruns Department of General, Visceral, Cancer and Transplantation Surgery University Hospital Cologne Biography Publications Institution JoVE Articles Christiane Bruns has not added a biography. If you are Christiane Bruns and would like to personalize this page please email our Author Liaison for assistance. Publications Targeted Therapy for Adrenocortical Carcinoma: A Genomic-Based Search for Available and Emerging Options Cancers. May, 2022 | Pubmed ID: 35681700 Resistance Mechanisms of the Metastatic Tumor Microenvironment to Anti-Angiogenic Therapy Frontiers in Oncology. 2022 | Pubmed ID: 35664794 Influence of Patient Sex on Outcomes After Pancreatic Surgery: Multicentre Study The British Journal of Surgery. May, 2022 | Pubmed ID: 35574811 Adrenal Surgery in the Era of Multidisciplinary Endocrine Tumor Boards Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. May, 2022 | Pubmed ID: 35533674 Fructose-1,6-bisphosphatase 1 (FBP1) is an Independent Biomarker Associated with a Favorable Prognosis in Esophageal Adenocarcinoma Journal of Cancer Research and Clinical Oncology. Apr, 2022 | Pubmed ID: 35477823 [Synopsis-S3 Guidelines Pancreatic Cancer] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. 05, 2022 | Pubmed ID: 35471458 Long-Term Outcome After Histopathological Complete Response with and Without Nodal Metastases Following Multimodal Treatment of Esophageal Cancer Annals of Surgical Oncology. Apr, 2022 | Pubmed ID: 35403919 International Tumor Budding Consensus Conference Criteria Determine the Prognosis of Oesophageal Adenocarcinoma with Poor Response to Neoadjuvant Treatment Pathology, Research and Practice. Apr, 2022 | Pubmed ID: 35316631 Anaplastic Thyroid Cancer: Genome-based Search for New Targeted Therapy Options Endocrine Connections. Apr, 2022 | Pubmed ID: 35275096 Expression of Neighbor of Punc E11 (NOPE) in Early Stage Esophageal Adenocarcinoma is Associated with Reduced Survival Scientific Reports. 03, 2022 | Pubmed ID: 35246597 Post-transplant Malignancies Show Reduced T-cell Abundance and Tertiary Lymphoid Structures As Correlates of Impaired Cancer Immunosurveillance Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. 04, 2022 | Pubmed ID: 35191474 Definitions and Treatment of Oligometastatic Oesophagogastric Cancer According to Multidisciplinary Tumour Boards in Europe European Journal of Cancer (Oxford, England : 1990). 03, 2022 | Pubmed ID: 35134666 T-cells of Invasive Candidiasis Patients Show Patterns of T-cell-exhaustion Suggesting Checkpoint Blockade As Treatment Option The Journal of Infection. 02, 2022 | Pubmed ID: 34921845 Gender Benefit in Laparoscopic Surgical Performance Using a 3D-display System: Data from a Randomized Cross-over Trial Surgical Endoscopy. Jun, 2022 | Pubmed ID: 34750707 Short-term Outcome of Ivor Lewis Esophagectomy Following Neoadjuvant Chemoradiation Versus Perioperative Chemotherapy in Patients with Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: a Propensity Score-matched Analysis Journal of Cancer Research and Clinical Oncology. May, 2022 | Pubmed ID: 34223965 [Multimodal Treatment of Esophageal Cancer] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Dec, 2021 | Pubmed ID: 34842948 Comparison of Outcomes Between Neoadjuvant Chemoradiotherapy and Neoadjuvant Chemotherapy in Patients with Locally Advanced Esophageal Cancer: A Network Meta-analysis EClinicalMedicine. Dec, 2021 | Pubmed ID: 34805809 IL-17B/RB Activation in Pancreatic Stellate Cells Promotes Pancreatic Cancer Metabolism and Growth Cancers. Oct, 2021 | Pubmed ID: 34771503 Different Prevalence of Alarm, Dyspeptic and Reflux Symptoms in Patients with Cardia and Non-cardia Gastric Cancer Journal of Gastrointestinal and Liver Diseases : JGLD. 12, 2021 | Pubmed ID: 34752588 A Novel Hybrid Stent with Endoscopic Vacuum Therapy for Treating Leaks of the Upper Gastrointestinal Tract Visceral Medicine. Oct, 2021 | Pubmed ID: 34722723 Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis Frontiers in Endocrinology. 2021 | Pubmed ID: 34630336 Tumor Microenvironment of Esophageal Cancer Cancers. Sep, 2021 | Pubmed ID: 34572905 [Impact of COVID-19 in Visceral Surgery] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. 10, 2021 | Pubmed ID: 34559260 Palliation of Malignant Dysphagia with a Segmented Self-expanding Metal Stent: A STROBE-compliant Article Medicine. Aug, 2021 | Pubmed ID: 34449494 Occurrence of High Microsatellite-Instability/Mismatch Repair Deficiency in Nearly 2,000 Human Adenocarcinomas of the Gastrointestinal Tract, Pancreas, and Bile Ducts: A Study From a Large German Comprehensive Cancer Center Frontiers in Oncology. 2021 | Pubmed ID: 34367937 Neoadjuvant Therapy for Resectable Pancreatic Cancer: A New Standard of Care. Pooled Data From 3 Randomized Controlled Trials Annals of Surgery. 11, 2021 | Pubmed ID: 34334656 Characteristics of Early-Onset Vs Late-Onset Colorectal Cancer: A Review JAMA Surgery. 09, 2021 | Pubmed ID: 34190968 CD86 Antigen-Presenting B Cells Are Increased in Cancer, Localize in Tertiary Lymphoid Structures, and Induce Specific T-cell Responses Cancer Immunology Research. 09, 2021 | Pubmed ID: 34155067 Cancer-specific Immune Evasion and Substantial Heterogeneity Within Cancer Types Provide Evidence for Personalized Immunotherapy NPJ Precision Oncology. Jun, 2021 | Pubmed ID: 34135436 Endoscopic Vacuum Therapy Versus Stent Treatment of Esophageal Anastomotic Leaks (ESOLEAK): Study Protocol for a Prospective Randomized Phase 2 Trial Trials. Jun, 2021 | Pubmed ID: 34078426 Aldo-Keto Reductase 1C3 Mediates Chemotherapy Resistance in Esophageal Adenocarcinoma Via ROS Detoxification Cancers. May, 2021 | Pubmed ID: 34065695 Sex-specific Prognostic Effect of CD66b-positive Tumor-infiltrating Neutrophils (TANs) in Gastric and Esophageal Adenocarcinoma Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 11, 2021 | Pubmed ID: 34009535 Optimized PD-L1 Scoring of Gastric Cancer Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association. 09, 2021 | Pubmed ID: 33954872 Technique of Open and Minimally Invasive Intrathoracic Reconstruction Following Esophagectomy-an Expert Consensus Based on a Modified Delphi Process Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus. Nov, 2021 | Pubmed ID: 33846718 Quiescin Sulfhydryl Oxidase 1 Promotes Sorafenib-induced Ferroptosis in Hepatocellular Carcinoma by Driving EGFR Endosomal Trafficking and Inhibiting NRF2 Activation Redox Biology. 05, 2021 | Pubmed ID: 33770521 [Robotics in Visceral Surgery] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Feb, 2021 | Pubmed ID: 33566135 Value of Spectral Detector CT for Pretherapeutic, Locoregional Assessment of Esophageal Cancer European Journal of Radiology. Jan, 2021 | Pubmed ID: 33302024 Microwave Ablation Enhances Tumor-specific Immune Response in Patients with Hepatocellular Carcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2021 | Pubmed ID: 33006650 Tumor Budding Assessed According to the Criteria of the International Tumor Budding Consensus Conference Determines Prognosis in Resected Esophageal Adenocarcinoma Virchows Archiv : an International Journal of Pathology. Mar, 2021 | Pubmed ID: 32761393 The Effect of Postoperative Complications After Minimally Invasive Esophagectomy on Long-term Survival: An International Multicenter Cohort Study Annals of Surgery. 12, 2021 | Pubmed ID: 31972650 GATA Binding Protein 6 (GATA6) is Co-amplified with PIK3CA in Patients with Esophageal Adenocarcinoma and is Linked to Neoadjuvant Therapy Journal of Cancer Research and Clinical Oncology. Dec, 2020 | Pubmed ID: 33300112 Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies Frontiers in Oncology. 2020 | Pubmed ID: 33194749 Interferon-Induced Protein With Multiple Tetratricopeptide Repeats 3 Is Associated With Response to Chemotherapy and Recurrence but Not With Survival Pancreas. Nov/Dec, 2020 | Pubmed ID: 33122518 Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma Journal of Immunology Research. 2020 | Pubmed ID: 33029538 3D Versus 4K Display System - Influence of "State-of-the-art"-Display Technique on Surgical Performance (IDOSP-study) in Minimally Invasive Surgery: A Randomized Cross-over Trial Annals of Surgery. 11, 2020 | Pubmed ID: 32833763 Inflammatory IFIT3 Renders Chemotherapy Resistance by Regulating Post-translational Modification of VDAC2 in Pancreatic Cancer Theranostics. 2020 | Pubmed ID: 32641986 Y Chromosome Loss is a Frequent Event in Barrett's Adenocarcinoma and Associated with Poor Outcome Cancers. Jun, 2020 | Pubmed ID: 32629877 Amplification of KRAS and Its Heterogeneity in Non-Asian Gastric Adenocarcinomas BMC Cancer. Jun, 2020 | Pubmed ID: 32571252 Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer Cells. 06, 2020 | Pubmed ID: 32560537 [Molecular Predictors for the Course of Disease and Individualized Therapy in Pancreatic Cancer] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Aug, 2020 | Pubmed ID: 32405728 Pelvic Exenteration Surgery in Patients with Locally Advanced Castration-naïve and Castration-resistant, Symptomatic Prostate Cancer BJU International. 09, 2020 | Pubmed ID: 32320130 Cathepsin D Expression and Gemcitabine Resistance in Pancreatic Cancer JNCI Cancer Spectrum. Feb, 2020 | Pubmed ID: 32296755 Cell Type-specific Transcriptomics of Esophageal Adenocarcinoma As a Scalable Alternative for Single Cell Transcriptomics Molecular Oncology. 06, 2020 | Pubmed ID: 32255255 Gastric Cancer in Autoimmune Gastritis: A Case-control Study from the German Centers of the StaR Project on Gastric Cancer Research United European Gastroenterology Journal. 03, 2020 | Pubmed ID: 32213076 [Neoadjuvant Chemoradiotherapy or Chemotherapy for Locally Advanced Esophageal Cancer?] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. May, 2020 | Pubmed ID: 32140748 [Bile Duct Surgery] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Jan, 2020 | Pubmed ID: 31960111 Immune Profile and Immunosurveillance in Treatment-naive and Neoadjuvantly Treated Esophageal Adenocarcinoma Cancer Immunology, Immunotherapy : CII. Apr, 2020 | Pubmed ID: 31960110 PIK3CA and KRAS Amplification In Esophageal Adenocarcinoma and Their Impact on the Inflammatory Tumor Microenvironment and Prognosis Translational Oncology. Feb, 2020 | Pubmed ID: 31865178 Tumor Biology and Multidisciplinary Strategies of Oligometastasis in Gastrointestinal Cancers Seminars in Cancer Biology. 02, 2020 | Pubmed ID: 31445220 Anastomotic Techniques and Associated Morbidity in Total Minimally Invasive Transthoracic Esophagectomy: Results From the EsoBenchmark Database Annals of Surgery. 11, 2019 | Pubmed ID: 31634181 Upregulation of MiR-17-92 Cluster is Associated with Progression and Lymph Node Metastasis in Oesophageal Adenocarcinoma Scientific Reports. 08, 2019 | Pubmed ID: 31431687 Tumor-Derived Extracellular Vesicles Inhibit Natural Killer Cell Function in Pancreatic Cancer Cancers. Jun, 2019 | Pubmed ID: 31234517 [Sarcoma-Established and New Aspects and Challenges in Multimodal Management] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Jun, 2019 | Pubmed ID: 31187213 Evaluation of Mechanical Properties of Segmented Esophageal Self-Expandable Metal Stents: Innovative Test Methods Are Needed Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A. Sep, 2019 | Pubmed ID: 31161950 Corrigendum to "Targeting Cancer Stem Cells and Their Niche: Perspectives for Future Therapeutic Targets and Strategies" [Semin. Cancer Biol. (2018) (August) Pii: S1044-579X(18)30045-2, 139-155] Seminars in Cancer Biology. Aug, 2019 | Pubmed ID: 30850316 HER2/neu (ERBB2) Expression and Gene Amplification Correlates with Better Survival in Esophageal Adenocarcinoma BMC Cancer. Jan, 2019 | Pubmed ID: 30621632 An Experimental Model of Breast Cancer Cells: Informative Protocol for Culture Anticancer Research. Nov, 2018 | Pubmed ID: 30396943 [Primary Hepatobiliary Malignancy] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Nov, 2018 | Pubmed ID: 30377728 Somatic Alterations in Circulating Cell-free DNA of Oesophageal Carcinoma Patients During Primary Staging Are Indicative for Post-surgical Tumour Recurrence Scientific Reports. 10, 2018 | Pubmed ID: 30297788 FA01.02: THE EFFECT OF POSTOPERATIVE COMPLICATIONS AFTER MIE ON LONG-TERM SURVIVAL: A RETROSPECTIVE, MULTI-CENTER COHORT STUDY Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus. Sep, 2018 | Pubmed ID: 30219910 Targeting Cancer Stem Cells and Their Niche: Perspectives for Future Therapeutic Targets and Strategies Seminars in Cancer Biology. 12, 2018 | Pubmed ID: 30081228 [Role of Visceral Surgery in Oligometastization] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Jul, 2018 | Pubmed ID: 29978326 Web-Based Immersive Patient Simulator As a Curricular Tool for Objective Structured Clinical Examination Preparation in Surgery: Development and Evaluation JMIR Serious Games. Jul, 2018 | Pubmed ID: 29973333 Update on Transumbilical Single-Incision Laparoscopic Assisted Appendectomy (TULAA) - Which Children Benefit and What Are the Complications? Klinische Padiatrie. Jul, 2018 | Pubmed ID: 29544230 [Oncological Surgery of the Stomach and Esophagus] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. 12, 2017 | Pubmed ID: 29177914 Defining Benchmarks for Transthoracic Esophagectomy: A Multicenter Analysis of Total Minimally Invasive Esophagectomy in Low Risk Patients Annals of Surgery. 11, 2017 | Pubmed ID: 28796646 [Range of Variation of Pancreaticojejunostomy in Pancreatic Head Resection] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Jan, 2017 | Pubmed ID: 28054106 [Different Techniques for Pancreatic Anastomosis] Der Chirurg; Zeitschrift Fur Alle Gebiete Der Operativen Medizen. Jan, 2017 | Pubmed ID: 27975123 Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion Ningbo Fan*1, Lisa Raatz*1, Seung-Hun Chon1, Alexander Quaas2, Christiane Bruns1, Yue Zhao1 1Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 2Institute of Pathology, University Hospital Cologne JoVE 63281 Cancer Research
Subculture and Cryopreservation of Esophageal Adenocarcinoma Organoids: Pros and Cons for Single Cell Digestion Ningbo Fan*1, Lisa Raatz*1, Seung-Hun Chon1, Alexander Quaas2, Christiane Bruns1, Yue Zhao1 1Department of General, Visceral, Cancer and Transplantation Surgery, University Hospital Cologne, 2Institute of Pathology, University Hospital Cologne JoVE 63281 Cancer Research