Paul C. Evans British Heart Foundation Cardiovascular Sciences Unit Imperial College London Biography Publications Institution JoVE Articles Paul C. Evans has not added a biography. If you are Paul C. Evans and would like to personalize this page please email our Author Liaison for assistance. Publications Targeting Inhibitor of Apoptosis Proteins to Block Vascular Inflammation Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2011 | Pubmed ID: 21918207 Heme Induces Heme Oxygenase 1 Via Nrf2: Role in the Homeostatic Macrophage Response to Intraplaque Hemorrhage Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2011 | Pubmed ID: 21868703 The Role of Blood Flow in Determining the Sites of Atherosclerotic Plaques F1000 Medicine Reports. 2011 | Pubmed ID: 21654925 Disturbed Blood Flow Induces RelA Expression Via C-Jun N-terminal Kinase 1: a Novel Mode of NF-κB Regulation That Promotes Arterial Inflammation Circulation Research. Apr, 2011 | Pubmed ID: 21350211 Do Miniaturized Extracorporeal Circuits Confer Significant Clinical Benefit Without Compromising Safety? A Meta-analysis of Randomized Controlled Trials ASAIO Journal (American Society for Artificial Internal Organs : 1992). May-Jun, 2011 | Pubmed ID: 21266906 Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-activated Protein Kinase Phosphatase-1: a Novel Antiinflammatory Treatment for Vein Grafts? Circulation. Feb, 2011 | Pubmed ID: 21262999 The Transcription Factor Erg Inhibits Vascular Inflammation by Repressing NF-kappaB Activation and Proinflammatory Gene Expression in Endothelial Cells Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2011 | Pubmed ID: 20966395 Smooth Muscle Cells in Porcine Vein Graft Intimal Hyperplasia Are Derived from the Local Vessel Wall Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology. May-Jun, 2011 | Pubmed ID: 20537564 Inhibition of NF-κB Signaling in Human Dendritic Cells by the Enteropathogenic Escherichia Coli Effector Protein NleE Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20833837 Role of Nuclear Factor KappaB in Cardiovascular Health and Disease Clinical Science (London, England : 1979). May, 2010 | Pubmed ID: 20175746 Celecoxib Activates PI-3K/Akt and Mitochondrial Redox Signaling to Enhance Heme Oxygenase-1-mediated Anti-inflammatory Activity in Vascular Endothelium Free Radical Biology & Medicine. Apr, 2010 | Pubmed ID: 20083195 C-Jun N-terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2010 | Pubmed ID: 20056910 Perfusion of Veins at Arterial Pressure Increases the Expression of KLF5 and Cell Cycle Genes in Smooth Muscle Cells Biochemical and Biophysical Research Communications. Jan, 2010 | Pubmed ID: 19958749 Activation of Nrf2 in Endothelial Cells Protects Arteries from Exhibiting a Proinflammatory State Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2009 | Pubmed ID: 19729611 Induction of the Cytoprotective Enzyme Heme Oxygenase-1 by Statins is Enhanced in Vascular Endothelium Exposed to Laminar Shear Stress and Impaired by Disturbed Flow The Journal of Biological Chemistry. Jul, 2009 | Pubmed ID: 19457866 Nur77: Orphaned at Birth but Adopted by the Nuclear Factor KappaB Signaling Pathway Circulation Research. Mar, 2009 | Pubmed ID: 19325155 The A20 Gene Protects Kidneys from Ischaemia/reperfusion Injury by Suppressing Pro-inflammatory Activation Journal of Molecular Medicine (Berlin, Germany). Dec, 2008 | Pubmed ID: 18813897 Hemodynamic Parameters Regulating Vascular Inflammation and Atherosclerosis: a Brief Update Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie. Oct, 2008 | Pubmed ID: 18757166 Increased Endothelial Mitogen-activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis Circulation Research. Sep, 2008 | Pubmed ID: 18723442 Hydrogen Peroxide Prolongs Nuclear Localization of NF-kappaB in Activated Cells by Suppressing Negative Regulatory Mechanisms The Journal of Biological Chemistry. Jul, 2008 | Pubmed ID: 18474597 Elevated P53 Expression is Associated with Dysregulation of the Ubiquitin-proteasome System in Dilated Cardiomyopathy Cardiovascular Research. Aug, 2008 | Pubmed ID: 18375498 KLF2-dependent, Shear Stress-induced Expression of CD59: a Novel Cytoprotective Mechanism Against Complement-mediated Injury in the Vasculature The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18362151 NF-kappaB Suppression by the Deubiquitinating Enzyme Cezanne: a Novel Negative Feedback Loop in Pro-inflammatory Signaling The Journal of Biological Chemistry. Mar, 2008 | Pubmed ID: 18178551 Effect of Shear Stress on Vascular Inflammation and Plaque Development Current Opinion in Lipidology. Oct, 2007 | Pubmed ID: 17885423 Laminar Shear Stress Acts As a Switch to Regulate Divergent Functions of NF-kappaB in Endothelial Cells FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2007 | Pubmed ID: 17557931 The Triage of Damaged Proteins: Degradation by the Ubiquitin-proteasome Pathway or Repair by Molecular Chaperones FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Apr, 2006 | Pubmed ID: 16469848 Regulation of Pro-inflammatory Signalling Networks by Ubiquitin: Identification of Novel Targets for Anti-inflammatory Drugs Expert Reviews in Molecular Medicine. Jun, 2005 | Pubmed ID: 15967057 Zinc-finger Protein A20, a Regulator of Inflammation and Cell Survival, Has De-ubiquitinating Activity The Biochemical Journal. Mar, 2004 | Pubmed ID: 14748687 A Novel Type of Deubiquitinating Enzyme The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12682062 Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice Michael T. Kuhlmann1, Simon Cuhlmann2,3, Irmgard Hoppe1, Rob Krams3, Paul C. Evans2, Gustav J. Strijkers4, Klaas Nicolay4, Sven Hermann1, Michael Schäfers1 1European Institute for Molecular Imaging, Westfälische Wilhelms-University Münster, 2British Heart Foundation Cardiovascular Sciences Unit, Imperial College London, 3Department of Bioengineering, Imperial College London, 4Biomedical Engineering, Eindhoven University of Technology JoVE 3308 Medicine
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice Michael T. Kuhlmann1, Simon Cuhlmann2,3, Irmgard Hoppe1, Rob Krams3, Paul C. Evans2, Gustav J. Strijkers4, Klaas Nicolay4, Sven Hermann1, Michael Schäfers1 1European Institute for Molecular Imaging, Westfälische Wilhelms-University Münster, 2British Heart Foundation Cardiovascular Sciences Unit, Imperial College London, 3Department of Bioengineering, Imperial College London, 4Biomedical Engineering, Eindhoven University of Technology JoVE 3308 Medicine