Ron Weiss Department of Biological Engineering Massachusetts Institute of Technology Biography Publications Institution JoVE Articles Ron Weiss has not added a biography. If you are Ron Weiss and would like to personalize this page please email our Author Liaison for assistance. Publications Cholesterol-Amino-Phosphate (CAP) Derived Lipid Nanoparticles for Delivery of Self-Amplifying RNA and Restoration of Spermatogenesis in Infertile Mice Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Feb, 2023 | Pubmed ID: 36748274 Synthetic Genetic Circuits to Uncover and Enforce the OCT4 Trajectories of Successful Reprogramming of Human Fibroblasts BioRxiv : the Preprint Server for Biology. Jan, 2023 | Pubmed ID: 36747813 The Sound of Silence: Transgene Silencing in Mammalian Cell Engineering Cell Systems. Dec, 2022 | Pubmed ID: 36549273 A Synthetic Transcription Platform for Programmable Gene Expression in Mammalian Cells Nature Communications. Oct, 2022 | Pubmed ID: 36257931 Synthetic Neuromorphic Computing in Living Cells Nature Communications. Sep, 2022 | Pubmed ID: 36153343 PERSIST Platform Provides Programmable RNA Regulation Using CRISPR EndoRNases Nature Communications. May, 2022 | Pubmed ID: 35562172 Robust and Tunable Signal Processing in Mammalian Cells Via Engineered Covalent Modification Cycles Nature Communications. Mar, 2022 | Pubmed ID: 35361767 Principles for the Design of Multicellular Engineered Living Systems APL Bioengineering. Mar, 2022 | Pubmed ID: 35274072 Meeting Measurement Precision Requirements for Effective Engineering of Genetic Regulatory Networks ACS Synthetic Biology. Mar, 2022 | Pubmed ID: 35156365 Quantitative Characterization of Recombinase-based Digitizer Circuits Enables Predictable Amplification of Biological Signals Communications Biology. Jul, 2021 | Pubmed ID: 34267310 An Engineered Protein-phosphorylation Toggle Network with Implications for Endogenous Network Discovery Science (New York, N.Y.). Jul, 2021 | Pubmed ID: 34210851 Context-aware Synthetic Biology by Controller Design: Engineering the Mammalian Cell Cell Systems. Jun, 2021 | Pubmed ID: 34139166 TASBE Image Analytics: A Processing Pipeline for Quantifying Cell Organization from Fluorescent Microscopy Methods in Molecular Biology (Clifton, N.J.). 2021 | Pubmed ID: 33340350 Rethinking Organoid Technology Through Bioengineering Nature Materials. Feb, 2021 | Pubmed ID: 33199860 In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying MRNA Regulation Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2021 | Pubmed ID: 33186690 Multifunctional Oncolytic Nanoparticles Deliver Self-replicating IL-12 RNA to Eliminate Established Tumors and Prime Systemic Immunity Nature Cancer. Sep, 2020 | Pubmed ID: 34447945 An Endoribonuclease-based Feedforward Controller for Decoupling Resource-limited Genetic Modules in Mammalian Cells Nature Communications. Nov, 2020 | Pubmed ID: 33173034 Correction: 3D Aggregation of Cells in Packed Microgel Media Soft Matter. Jul, 2020 | Pubmed ID: 32639490 3D Aggregation of Cells in Packed Microgel Media Soft Matter. Jul, 2020 | Pubmed ID: 32589183 Principles of Synthetic Biology: a MOOC for an Emerging Field Synthetic Biology (Oxford, England). 2019 | Pubmed ID: 32995535 Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles Molecular Therapy : the Journal of the American Society of Gene Therapy. 12, 2019 | Pubmed ID: 31515132 A 'poly-transfection' Method for Rapid, One-pot Characterization and Optimization of Genetic Systems Nucleic Acids Research. 10, 2019 | Pubmed ID: 31372658 A High-throughput Screening and Computation Platform for Identifying Synthetic Promoters with Enhanced Cell-state Specificity (SPECS) Nature Communications. 06, 2019 | Pubmed ID: 31253799 Small-molecule Control of Antibody N-glycosylation in Engineered Mammalian Cells Nature Chemical Biology. 07, 2019 | Pubmed ID: 31110306 In Vitro Evolution of Enhanced RNA Replicons for Immunotherapy Scientific Reports. 05, 2019 | Pubmed ID: 31061426 An Artificial Tissue Homeostasis Circuit Designed Via Analog Circuit Techniques IEEE Transactions on Biomedical Circuits and Systems. Jun, 2019 | Pubmed ID: 30908238 Dissecting N-Glycosylation Dynamics in Chinese Hamster Ovary Cells Fed-batch Cultures Using Time Course Omics Analyses IScience. Feb, 2019 | Pubmed ID: 30682623 Comparison of Integrases Identifies Bxb1-GA Mutant As the Most Efficient Site-Specific Integrase System in Mammalian Cells ACS Synthetic Biology. 01, 2019 | Pubmed ID: 30609349 Perspective: The Promise of Multi-cellular Engineered Living Systems APL Bioengineering. Dec, 2018 | Pubmed ID: 31069321 Author Correction: A Mixed Antagonistic/synergistic MiRNA Repression Model Enables Accurate Predictions of Multi-input MiRNA Sensor Activity Nature Communications. 11, 2018 | Pubmed ID: 30389927 Engineering Protein-protein Devices for Multilayered Regulation of MRNA Translation Using Orthogonal Proteases in Mammalian Cells Nature Communications. 10, 2018 | Pubmed ID: 30349044 Small-molecule-based Regulation of RNA-delivered Circuits in Mammalian Cells Nature Chemical Biology. 11, 2018 | Pubmed ID: 30327560 A Mixed Antagonistic/synergistic MiRNA Repression Model Enables Accurate Predictions of Multi-input MiRNA Sensor Activity Nature Communications. 06, 2018 | Pubmed ID: 29934631 Stochastic Turing Patterns in a Synthetic Bacterial Population Proceedings of the National Academy of Sciences of the United States of America. 06, 2018 | Pubmed ID: 29891706 Engineering Modular Intracellular Protein Sensor-actuator Devices Nature Communications. 05, 2018 | Pubmed ID: 29760420 A Multi-landing Pad DNA Integration Platform for Mammalian Cell Engineering Nucleic Acids Research. 05, 2018 | Pubmed ID: 29617873 Programming Gene and Engineered-cell Therapies with Synthetic Biology Science (New York, N.Y.). 02, 2018 | Pubmed ID: 29439214 A Modular Approach to Building Complex Synthetic Circuits Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28801911 Open-source, Community-driven Microfluidics with Metafluidics Nature Biotechnology. 06, 2017 | Pubmed ID: 28591125 A Novel Bxb1 Integrase RMCE System for High Fidelity Site-specific Integration of MAb Expression Cassette in CHO Cells Biotechnology and Bioengineering. 08, 2017 | Pubmed ID: 28186334 Synthetic Morphogenesis Cold Spring Harbor Perspectives in Biology. Sep, 2016 | Pubmed ID: 27270296 Genetically Engineering Self-organization of Human Pluripotent Stem Cells into a Liver Bud-like Tissue Using Gata6 Nature Communications. Jan, 2016 | Pubmed ID: 26732624 Cas9 GRNA Engineering for Genome Editing, Activation and Repression Nature Methods. Nov, 2015 | Pubmed ID: 26344044 N(1)-methylpseudouridine-incorporated MRNA Outperforms Pseudouridine-incorporated MRNA by Providing Enhanced Protein Expression and Reduced Immunogenicity in Mammalian Cell Lines and Mice Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2015 | Pubmed ID: 26342664 SYNTHETIC BIOLOGY. Synthetic Communities, the Sum of Parts Science (New York, N.Y.). Aug, 2015 | Pubmed ID: 26315419 Preserved DNA Damage Checkpoint Pathway Protects Against Complications in Long-Standing Type 1 Diabetes Cell Metabolism. Aug, 2015 | Pubmed ID: 26244933 Isocost Lines Describe the Cellular Economy of Genetic Circuits Biophysical Journal. Aug, 2015 | Pubmed ID: 26244745 Mammalian Synthetic Circuits with RNA Binding Proteins for RNA-only Delivery Nature Biotechnology. Aug, 2015 | Pubmed ID: 26237515 Highly Efficient Cas9-mediated Transcriptional Programming Nature Methods. Apr, 2015 | Pubmed ID: 25730490 Modular Construction of Mammalian Gene Circuits Using TALE Transcriptional Repressors Nature Chemical Biology. Mar, 2015 | Pubmed ID: 25643171 Accurate Predictions of Genetic Circuit Behavior from Part Characterization and Modular Composition ACS Synthetic Biology. Jun, 2015 | Pubmed ID: 25369267 A Load Driver Device for Engineering Modularity in Biological Networks Nature Biotechnology. Dec, 2014 | Pubmed ID: 25419739 Rapid Neurogenesis Through Transcriptional Activation in Human Stem Cells Molecular Systems Biology. Nov, 2014 | Pubmed ID: 25403753 A Platform for Rapid Prototyping of Synthetic Gene Networks in Mammalian Cells Nucleic Acids Research. Dec, 2014 | Pubmed ID: 25378321 Systematic Transfer of Prokaryotic Sensors and Circuits to Mammalian Cells ACS Synthetic Biology. Dec, 2014 | Pubmed ID: 25360681 CRISPR Transcriptional Repression Devices and Layered Circuits in Mammalian Cells Nature Methods. Jul, 2014 | Pubmed ID: 24797424 Realizing the Potential of Synthetic Biology Nature Reviews. Molecular Cell Biology. 04, 2014 | Pubmed ID: 24622617 Microbead-based Biomimetic Synthetic Neighbors Enhance Survival and Function of Rat Pancreatic β-cells Scientific Reports. Oct, 2013 | Pubmed ID: 24091640 Rapid, Modular and Reliable Construction of Complex Mammalian Gene Circuits Nucleic Acids Research. Sep, 2013 | Pubmed ID: 23847100 Genetically Programmable Pathogen Sense and Destroy ACS Synthetic Biology. Dec, 2013 | Pubmed ID: 23763381 Formation and Optogenetic Control of Engineered 3D Skeletal Muscle Bioactuators Lab on a Chip. Dec, 2012 | Pubmed ID: 22976544 Modular Design of Artificial Tissue Homeostasis: Robust Control Through Synthetic Cellular Heterogeneity PLoS Computational Biology. 2012 | Pubmed ID: 22829755 Foundations for the Design and Implementation of Synthetic Genetic Circuits Nature Reviews. Genetics. May, 2012 | Pubmed ID: 22596318 Understanding Signaling Dynamics Through Synthesis Science Signaling. Apr, 2012 | Pubmed ID: 22510466 Automatic Compilation from High-level Biologically-oriented Programming Language to Genetic Regulatory Networks PloS One. 2011 | Pubmed ID: 21850228 Design and Connection of Robust Genetic Circuits Methods in Enzymology. 2011 | Pubmed ID: 21601086 Rapid Development of Cell State Identification Circuits with Poly-Transfection Noreen Wauford1, Ross Jones1,2, Charles Van De Mark3, Ron Weiss1,3 1Department of Biological Engineering, Massachusetts Institute of Technology, 2School of Biological Engineering, University of British Columbia, 3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology JoVE 64793 Bioengineering Engineering Intracellular Protein Sensors in Mammalian Cells Marina Duhkinova1, Claudia Crina1, Ron Weiss2, Velia Siciliano1 1Istituto Italiano di Tecnologia, 2Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology JoVE 60878 Genetics
Rapid Development of Cell State Identification Circuits with Poly-Transfection Noreen Wauford1, Ross Jones1,2, Charles Van De Mark3, Ron Weiss1,3 1Department of Biological Engineering, Massachusetts Institute of Technology, 2School of Biological Engineering, University of British Columbia, 3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology JoVE 64793 Bioengineering
Engineering Intracellular Protein Sensors in Mammalian Cells Marina Duhkinova1, Claudia Crina1, Ron Weiss2, Velia Siciliano1 1Istituto Italiano di Tecnologia, 2Synthetic Biology Center, Department of Biological Engineering, Massachusetts Institute of Technology JoVE 60878 Genetics
