Weiwei Guo College of Otolaryngology Head and Neck Surgery Chinese PLA General Hospital Biography Publications Institution JoVE Articles Weiwei Guo has not added a biography. If you are Weiwei Guo and would like to personalize this page please email our Author Liaison for assistance. Publications LDL Receptor-related Protein 1 (LRP1), a Novel Target for Opening the Blood-labyrinth Barrier (BLB) Signal Transduction and Targeted Therapy. Jun, 2022 | Pubmed ID: 35680846 Head and Neck Radiotherapy Causes Significant Disruptions of Cochlear Ribbon Synapses and Consequent Sensorineural Hearing Loss Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology. May, 2022 | Pubmed ID: 35640772 Correction To: Sox10 Gene Is Required for the Survival of Saccular and Utricular Hair Cells in a Porcine Model Molecular Neurobiology. Jun, 2022 | Pubmed ID: 35394610 Sox10 Gene Is Required for the Survival of Saccular and Utricular Hair Cells in a Porcine Model Molecular Neurobiology. Jun, 2022 | Pubmed ID: 35249166 Exploratory Saccades Data Analysis of Video Head Impulse Test in Different Meniere's Disease Stages Journal of Vestibular Research : Equilibrium & Orientation. 2022 | Pubmed ID: 34366304 CRISPR/Cas9-mediated Correction of Homozygous Point Mutation in a Waardenburg Syndrome 2A Pig Model Molecular Therapy. Nucleic Acids. Jun, 2021 | Pubmed ID: 34094716 Electrophysiological and Histomorphological Changes of Cochlea in Miniature Pigs After Abrasion of Round Window Niches Acta Oto-laryngologica. Jun, 2021 | Pubmed ID: 33881381 Oridonin Ameliorates Noise-induced Hearing Loss by Blocking NLRP3 - NEK7 Mediated Inflammasome Activation International Immunopharmacology. Jun, 2021 | Pubmed ID: 33770730 Air and Bone-conducted Vestibular Evoked Myogenic Potentials in Children with Large Vestibular Aqueduct Syndrome Acta Oto-laryngologica. Jan, 2021 | Pubmed ID: 32964775 The Characteristics of VHIT Gain and PR Score in Peripheral Vestibular Disorders Acta Oto-laryngologica. Jan, 2021 | Pubmed ID: 32930021 Phenotypic Similarities in Pigs with SOX10 and SOX10 Mutations Implied the Correlation of SOX10 Haploinsufficiency with Waardenburg Syndrome Journal of Genetics and Genomics = Yi Chuan Xue Bao. 12, 2020 | Pubmed ID: 33766494 KIT Gene Mutation Causes Deafness and Hypopigmentation in Bama Miniature Pigs American Journal of Translational Research. 2020 | Pubmed ID: 33042408 Transplantation and Tracking of the Human Umbilical Cord Mesenchymal Stem Cell Labeled with Superparamagnetic Iron Oxide in Deaf Pigs Anatomical Record (Hoboken, N.J. : 2007). 03, 2020 | Pubmed ID: 31943852 Establishment of a Large Animal Model for Eustachian Tube Functional Study in Miniature Pigs Anatomical Record (Hoboken, N.J. : 2007). Feb, 2019 | Pubmed ID: 30779320 Degeneration of Saccular Hair Cells Caused by MITF Gene Mutation Neural Development. 01, 2019 | Pubmed ID: 30635004 Rapid Analysis of Neomycin in Cochlear Perilymph of Guinea Pigs Using Disposable SPE Cartridges and High Performance Liquid Chromatography-tandem Mass Spectrometry Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2018 | Pubmed ID: 29990713 Differential Fates of Tissue Macrophages in the Cochlea During Postnatal Development Hearing Research. 08, 2018 | Pubmed ID: 29804721 Cochlear Morphology in the Developing Inner Ear of the Porcine Model of Spontaneous Deafness BMC Neuroscience. 05, 2018 | Pubmed ID: 29716524 NLRP3-inflammasomes Are Triggered by Age-related Hearing Loss in the Inner Ear of Mice American Journal of Translational Research. 2017 | Pubmed ID: 29312513 Creation of Miniature Pig Model of Human Waardenburg Syndrome Type 2A by ENU Mutagenesis Human Genetics. 11, 2017 | Pubmed ID: 29094203 Transcription Analysis of Cochlear Development in Minipigs Acta Oto-laryngologica. Nov, 2017 | Pubmed ID: 28715930 Pilot Study of Large-scale Production of Mutant Pigs by ENU Mutagenesis ELife. 06, 2017 | Pubmed ID: 28639938 Matrix Metalloproteinase-2 and -9 Contribute to Functional Integrity and Noise‑induced Damage to the Blood-labyrinth-barrier Molecular Medicine Reports. Aug, 2017 | Pubmed ID: 28627704 Adeno-associated Virus Transformation into the Normal Miniature Pig and the Normal Guinea Pigs Cochlea Via Scala Tympani Acta Oto-laryngologica. Sep, 2017 | Pubmed ID: 28471702 The Morphological and Functional Development of the Stria Vascularis in Miniature Pigs Reproduction, Fertility, and Development. Mar, 2017 | Pubmed ID: 28442065 Establishing the Standard Method of Cochlear Implant in Rongchang Pig Acta Oto-laryngologica. May, 2017 | Pubmed ID: 28079462 Aminoglycoside Increases Permeability of Osseous Spiral Laminae of Cochlea by Interrupting MMP-2 and MMP-9 Balance Neurotoxicity Research. 04, 2017 | Pubmed ID: 28005182 Miniature Pigs: a Large Animal Model of Cochlear Implantation American Journal of Translational Research. 2016 | Pubmed ID: 28078020 Transplantation of Human Umbilical Cord Mesenchymal Stem Cells in Cochlea to Repair Sensorineural Hearing American Journal of Translational Research. 2016 | Pubmed ID: 28077998 A De Novo Silencer Causes Elimination of MITF-M Expression and Profound Hearing Loss in Pigs BMC Biology. 06, 2016 | Pubmed ID: 27349893 DAPT Mediates Atoh1 Expression to Induce Hair Cell-like Cells American Journal of Translational Research. 2016 | Pubmed ID: 27158355 SMAD4 Defect Causes Auditory Neuropathy Via Specialized Disruption of Cochlear Ribbon Synapses in Mice Molecular Neurobiology. 10, 2016 | Pubmed ID: 26491026 Inflammasome Activation in Mouse Inner Ear in Response to MCMV Induced Hearing Loss Journal of Otology. Dec, 2015 | Pubmed ID: 29937798 Advantages of a Miniature Pig Model in Research on Human Hereditary Hearing Loss Journal of Otology. Sep, 2015 | Pubmed ID: 29937791 Transcript Variants and Expression Profiles Analysis of Gene in Minipigs Journal of Otology. Jun, 2015 | Pubmed ID: 29937787 Overexpression of ROCK1 and ROCK2 Inhibits Human Laryngeal Squamous Cell Carcinoma International Journal of Clinical and Experimental Pathology. 2015 | Pubmed ID: 25755711 The Morphology and Electrophysiology of the Cochlea of the Miniature Pig Anatomical Record (Hoboken, N.J. : 2007). Mar, 2015 | Pubmed ID: 25394601 Spontaneous and Partial Repair of Ribbon Synapse in Cochlear Inner Hair Cells After Ototoxic Withdrawal Molecular Neurobiology. Dec, 2015 | Pubmed ID: 25377793 Profiles of the Auditory Epithelia Related MicroRNA Expression in Neonatal and Adult Rats European Journal of Medical Research. Sep, 2014 | Pubmed ID: 25192719 Hydrogen-saturated Saline Protects Intensive Narrow Band Noise-induced Hearing Loss in Guinea Pigs Through an Antioxidant Effect PloS One. 2014 | Pubmed ID: 24945316 De Novo Mutation in ATP6V1B2 Impairs Lysosome Acidification and Causes Dominant Deafness-onychodystrophy Syndrome Cell Research. Jun, 2014 | Pubmed ID: 24913193 Tonotopic Reorganization and Spontaneous Firing in Inferior Colliculus During Both Short and Long Recovery Periods After Noise Overexposure Journal of Biomedical Science. 2013 | Pubmed ID: 24320109 Molecular Epidemiology and Functional Assessment of Novel Allelic Variants of SLC26A4 in Non-syndromic Hearing Loss Patients with Enlarged Vestibular Aqueduct in China PloS One. 2012 | Pubmed ID: 23185506 Expression and Clinical Significance of Cathepsin B and Stefin A in Laryngeal Cancer Oncology Reports. Oct, 2011 | Pubmed ID: 21667036 [Establishment of Conditionally Immortalized Rat Cochlear Greater Epithelial Ridge and Lesser Epithelial Ridge Cell Lines Using a Retrovirus-mediated Gene Transfer Technique] Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology. May, 2006 | Pubmed ID: 16883794 [The Significance of the Interaural Latency Difference of VEMP] Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology. May, 2005 | Pubmed ID: 16108316 [The Saccular Function in Meniere's Disease] Lin Chuang Er Bi Yan Hou Ke Za Zhi = Journal of Clinical Otorhinolaryngology. Jul, 2004 | Pubmed ID: 15499976 Correlation of Cochlear Blood Supply with Mitochondrial DNA Common Deletion in Presbyacusis Acta Oto-laryngologica. Mar, 2004 | Pubmed ID: 15072414 [A Report on a Large Family with X-linked Recessive Nonsyndromic Hereditary Low Frequency Neuropathic Hearing Impairment] Zhonghua Er Bi Yan Hou Ke Za Zhi. Aug, 2002 | Pubmed ID: 12772406 The Miniature Pig: A Large Animal Model for Cochlear Implant Research Xiaojun Ji*1,2,3,4, Yi Luo*1,2,3,4, Weiwei Guo1,2,3,4, Fei Ji1,2,3,4, Shuolong Yuan1,2,3,4, Liangwei Xu1,2,3,4, Wei Chen*1,2,3,4 1College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, 2National Clinical Research Center for Otolaryngologic Diseases, 3Key Lab of Hearing Science, Ministry of Education, 4Beijing Key Lab of Hearing Impairment for Prevention and Treatment JoVE 64174 Medicine
The Miniature Pig: A Large Animal Model for Cochlear Implant Research Xiaojun Ji*1,2,3,4, Yi Luo*1,2,3,4, Weiwei Guo1,2,3,4, Fei Ji1,2,3,4, Shuolong Yuan1,2,3,4, Liangwei Xu1,2,3,4, Wei Chen*1,2,3,4 1College of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, 2National Clinical Research Center for Otolaryngologic Diseases, 3Key Lab of Hearing Science, Ministry of Education, 4Beijing Key Lab of Hearing Impairment for Prevention and Treatment JoVE 64174 Medicine
