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Mapping Cerebral Blood Flow and Electrical Fields: Electrode Placement in Mice

Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model (Video) | JoVE

Stimulation-Based Approach to Improve Cerebral Blood Flow in Alzheimer's Model (Video) | JoVE

02:13 min

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Surgery for Stimulating Electrode Placement and Burr Hole Creation in Mouse (Video) | JoVE

Surgery for Stimulating Electrode Placement and Burr Hole Creation in Mouse (Video) | JoVE

04:44 min

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Simone Degan¹, Yu Feng¹, Ulrike Hoffmann², Dennis A. Turner^1,3,4,5

¹Department of Neurosurgery, Duke University Medical Center, ²Department of Anesthesiology and Pain Management, University Texas Southwestern Medical School, ³Department of Neurobiology, Duke University Medical Center, ⁴Department of Biomedical Engineering, Duke University, ⁵Research and Surgery Services, Durham VA Medical Center

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我们描述了一种评估颅外刺激剂量反应曲线的方案，包括脑电场测量和相关的生物标志物-脑血流。由于该方案涉及将侵入性电极植入大脑，因此需要全身麻醉，首选自主呼吸而不是控制呼吸。

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