JoVE Journal
Biology
Biology
这篇 内容 是开放权限的.
章节
总结概括
Please note that all translations are automatically generated.
We provide a method for testing BRCA1 variants in a tissue culture based assay for homologous recombination repair of DNA damage by depleting endogenous BRCA1 protein from a cell using RNAi and replacing it with a BRCA1 point mutant that contains a coding change.