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Immunology and Infection

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Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Article DOI: 10.3791/64868-v • 09:02 min • September 22nd, 2023
September 22nd, 2023 •
1,2, 1,2, 3,4, 1,2, 3,4
1Department of Microbiology, University of Pennsylvania, 2Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania, 3Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, 4Corporal Michael J. Crescenz VA Medical Center

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The nasal epithelium is the primary barrier site encountered by all respiratory pathogens. Here, we outline methods to use primary nasal epithelial cells grown as air-liquid interface (ALI) cultures to characterize human coronavirus-host interactions in a physiologically relevant system.

Tags

Infection Primary Nasal Epithelial Cells Air-liquid Interface Human Coronavirus Host Interactions SARS-CoV MERS-CoV SARS-CoV-2 HCoV-NL63 HCoV-229E HCoV-OC43 HCoV-HKU1 Respiratory Tract Nasal Epithelium Patient-derived Nasal Samples Host-pathogen Interactions Airway Ciliary Function Mucus Production Viral Replication Host Cell Tropism Virus-induced Cytotoxicity Innate Immune Induction Antiviral Therapeutics
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