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Journal / Immunology and Infection / 利用衣壳抗原掺入战略的腺病毒血清型5载体疫苗方法的发展…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
利用衣壳抗原掺入战略的腺病毒血清型5载体疫苗方法的发展
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利用衣壳抗原掺入战略的腺病毒血清型5载体疫苗方法的发展

Article DOI: 10.3791/52655-v • 13:36 min • May 6th, 2015
May 6th, 2015 •
1, 1, 1, 1,2
1Department of Medicine, University of Alabama at Birmingham, 2Center for AIDS Research, University of Alabama at Birmingham

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在这里，我们提出了一个协议，以产生证明性的原则，二价5型腺病毒（Ad5的）载体的Ad5 / H5-HVR1-KWAS-HVR5-他6通过利用衣壳抗原掺入策略。此载体被证明表现出定性的健身，能力逃脱的Ad5阳性血清在体外 ，和抗原性以及免疫原性的结合抗原。

Tags

免疫学，第99，抗原衣壳-团策略，转基因的方法，腺病毒（广告），疫苗，衣壳蛋白，双修饰，预先存在的免疫性（PEI）
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