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Germinal Center: The activated center of a lymphoid follicle in secondary lymphoid tissue where B-Lymphocytes are stimulated by antigens and helper T cells (T-Lymphocytes, Helper-inducer) are stimulated to generate memory cells.

Highly Resolved Intravital Striped-illumination Microscopy of Germinal Centers

1Biophysical Analytics, German Rheumatism Research Center, Leibniz Institute, 2Microscopy Core Facility, Max-Delbrück Center for Molecular Medicine, 3Immunodynamics, German Rheumatism Research Center, Leibniz Institute, 4LaVision Biotec GmbH, 5Immunodynamics and Intravital Imaging, Charité - University of Medicine

JoVE 51135


 Immunology and Infection

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

1Department of Laboratory Medicine, AnSteel Group General Hospital, 2Cancer Science Institute of Singapore, National University of Singapore, 3Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, 4Department of Haematology-Oncology, National University Health System

Video Coming Soon

JoVE 58711


 JoVE In-Press

Automated Multiplex Immunofluorescence Panel for Immuno-oncology Studies on Formalin-fixed Carcinoma Tissue Specimens

1Laboratory of Pathology, MedImmune, 2Laboratory of Pathology, MedImmune, 3Perkin Elmer, Inc., 4Department of Translational Molecular Pathology, University of Texas - MD Anderson Cancer Center

Video Coming Soon

JoVE 58390


 JoVE In-Press

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

1PARCC-INSERM U970, Université Paris Descartes, 2INSERM U970, Université Paris Descartes, 3Equipe Labellisée Ligue Contre le Cancer, 4Department of Immunology, Hopital Européen Georges Pompidou, 5Department of Medical Urology, Hopital Européen Georges Pompidou, 6Department of Pathology, Hopital Européen Georges Pompidou, 7Université Paris Diderot Paris 7, 8Department of medical oncology, Hopital Européen Georges Pompidou

JoVE 56606


 Cancer Research

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