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Receptor, PAR-2: A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including Endothelium; Leukocytes; and the Gastrointestinal tract. The receptor is activated by Trypsin, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated Thrombin receptor and by small synthetic peptides that contain the unmasked N-terminal sequence.
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