Skip to content
Show Advanced Search
A G-protein-coupled, proteinase-activated receptor that is expressed in a variety of tissues including Endothelium; Leukocytes; and the Gastrointestinal tract. The receptor is activated by Trypsin, which cleaves off the N-terminal peptide from the receptor. The new N-terminal peptide is a cryptic ligand for the receptor. The uncleaved receptor can also be activated by the N-terminal peptide present on the activated Thrombin receptor and by small synthetic peptides that contain the unmasked N-terminal sequence.
1Department of Hemostasis and Thrombosis, Leiden University Medical Center
Get cutting-edge science videos from JoVE sent straight to your inbox every month.