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February 08, 2015
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Cancer is a complex disease that is influenced by the tissue surrounding the tumor as well as local pro- and anti-inflammatory mediators. Therefore, orthotropic injection models, rather than subcutaneous models may be useful to study cancer progression in a manner that better mimics human pathology.
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Kocatürk, B., Versteeg, H. H. Orthotopic Injection of Breast Cancer Cells into the Mammary Fat Pad of Mice to Study Tumor Growth.. J. Vis. Exp. (96), e51967, doi:10.3791/51967 (2015).
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