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Tissue Inhibitor of Metalloproteinases: A family of secreted proteins (Timp-1; Timp-2; and Timp-3) that play a crucial role in regulating the activity of the secreted Metalloendopeptidases; (Collagenases; stromelysins; Gelatinases). Of the three characterized, only Timp-1 and Timp-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

1The Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 2Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, 3Trauma Office, Children's National Health System

JoVE 56761


 Cancer Research

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

1Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University of Tübingen, 2Department of Nuclear Medicine, Eberhard Karls University of Tübingen, 3Department of Dermatology, Eberhard Karls University of Tübingen

JoVE 55180


 Immunology and Infection

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