Show Advanced Search

REFINE YOUR SEARCH:

Containing Text
- - -
+
Filter by author or institution
GO
Filter by publication date
From:
October, 2006
Until:
Today
Filter by journal section

Filter by science education

 
 
Tissue Inhibitor of Metalloproteinases: A family of secreted proteins (Timp-1; Timp-2; and Timp-3) that play a crucial role in regulating the activity of the secreted Metalloendopeptidases; (Collagenases; stromelysins; Gelatinases). Of the three characterized, only Timp-1 and Timp-2 appear to have related primary structures and inhibitory properties. They influence the activation of the prometalloproteinase and act to modulate proteolysis of extracellular matrix, notably during tissue remodeling and inflammatory processes. On certain cell types, they can exhibit growth factor-like activity, and they can inhibit the tumorigenic and metastatic phenotype in cancer cells. (Pharmacol Ther 1993;59:329-41)
More Results...