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Neo-Islet Vorming in de lever van muizen met diabetes door Helper-afhankelijke adenovirale vector-gemedieerde genoverdracht
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Neo-Islet Vorming in de lever van muizen met diabetes door Helper-afhankelijke adenovirale vector-gemedieerde genoverdracht

Article DOI: 10.3791/4321-v • 16:59 min • October 10th, 2012
October 10th, 2012 •
1,2, 1,2,3, 1,2,3
1Department of Medicine, Baylor College of Medicine, 2Division of Diabetes, Endocrinology & Metabolism, Diabetes & Endocrinology Research Center, Baylor College of Medicine, 3Department of Molecular & Cellular Biology, Baylor College of Medicine

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We beschrijven de lever neo-eilandje formatie in STZ (streptozotocine)-geïnduceerde diabetische muizen door genoverdracht van Neurogenin3 (Ngn3) en betacelluline (BTC) met behulp van helper-afhankelijke adenovirale vector (HDAd) en de omkering van hyperglycemie. Onze methode wordt voordelen van helper-afhankelijke adenovirale vectoren met hun zeer efficiënt in vivo transductie en langdurige genexpressie.

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Geneeskunde genetica fysiologie Gentherapie Neurogenin3 betacelluline helper-afhankelijke adenovirale vectoren type 1 diabetes eilandje neogenese
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