Direct Re-implantation of Left Coronary Artery into the Aorta in Adults with Anomalous Origin of Left Coronary Artery from the Pulmonary Artery (ALCAPA)

Summary

Surgical correction of ALCAPA is highly recommended, regardless of age or the degree of intercoronary collateralization. This protocol presents a technique for the direct re-implantation of adult-type ALCAPA into the aorta to re-establish the dual-coronary perfusion. Whenever feasible, direct re-implantation is preferred to other surgical correction techniques.

Abstract

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly which is one of leading causes of myocardial ischemia and infarction in children. If left untreated, it results in a 90% mortality rate in the first year of life. In patients who survive to the adulthood, the coronary steal phenomenon and retrograde left-sided coronary flow provide a substrate for chronic subendocardial ischemia, which may lead to left ventricular dysfunction, ischemic mitral regurgitation, malignant ventricular arrhythmias, and sudden cardiac death. The average age of life-threatening presentation is 33 years and of sudden cardiac death 31 years. Therefore, surgical correction is highly recommended as soon as the diagnosis is made, regardless of age. In adult-type ALCAPA originating from the right-facing sinus of the pulmonary artery, direct re-implantation of the ALCAPA into the aorta is the more physiologically sound repair technique to re-establish the dual-coronary perfusion system and is recommended. This protocol describes the technique of direct re-implantation of adult-type ALCAPA into the aorta.

Introduction

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital anomaly usually seen as an isolated lesion¹. The incidence of ALCAPA is estimated at 1 in 300,000 live births, comprising between 0.24% and 0.46% of congenital cardiac diseases^2,3. It is one of the most common causes of myocardial ischemia and infarction in children and, if left untreated, results in a 90% mortality rate in the first year of life⁴. Only 10 - 15% of infants survive to adulthood due to the rapid development of a large dominant right coronary artery (RCA) with extensive intercoronary collaterals⁴. During the neonatal period, high pulmonary vascular resistance and the resultant pulmonary artery (PA) pressures ensure that antegrade flow is maintained from the PA into the anomalous left coronary artery. As the pulmonary vascular resistance gradually decreases, antegrade flow to the left coronary artery reduces. This eventually leads to reversal of flow, and left-to-right shunting into the PA, thus resulting in a "coronary steal⁵." Thus, left ventricular (LV) myocardial perfusion depends on intercoronary collaterals from an RCA^5,6.

The coronary steal phenomenon and retrograde left-sided coronary flow provide a substrate for chronic subendocardial ischemia, which may lead to left ventricular dysfunction, ischemic mitral regurgitation, and malignant ventricular arrhythmias precipitated by acute myocardial ischemia⁷. In a subset of adult patients, the mean age at presentation is 41 years, with a shift in sex distribution toward female patients (Female-to-male ratio: 2:1)⁸. In this patient population, 14% are asymptomatic; 66% present with symptoms of angina, dyspnea, palpitations, or fatigue; and 17% present with life-threatening symptoms, including ventricular arrhythmias, syncope, and sudden cardiac death⁸. The average age of life-threatening presentation is 33 years and of sudden cardiac death 31 years⁸. Therefore, surgical correction is highly recommended as soon as the diagnosis is made, regardless of age or the degree of intercoronary collateralization^1,9.

Depending on the origin of the anomalous left coronary artery, direct re-implantation of the ALCAPA into the aorta is the more physiologically sound repair technique to reestablish the dual-coronary perfusion system. Most commonly, ALCAPA takes off from the right-hand pulmonary sinus (sinus 1 of the PA), which faces the aortic sinus where the main left coronary artery usually originates (sinus 2 of the aorta)¹⁰. This coronary anatomy is most suited to the direct re-implantation technique. The aim of this report is to describe, in detail, the technique for the direct re-implantation of the left coronary artery in ALCAPA in adult patients. The rationale behind direct re-implantation is the advantage-the physiological reestablishment of dual-coronary perfusion-it offers over the ligation of the anomalous left coronary combined with coronary artery bypass grafting^11,12,13.

Protocol

The protocol follows the institutional guidelines of the human research ethics committee of the University of Zurich.

1. Preparation for Surgery

1. Clean and prepare the surgical suite in a typical manner. To facilitate communication between the surgeon and the perfusionist, place the heart-lung machine to the left of the patient, opposite to the surgeon.
2. Pre-medicate the patient by the oral administration of 5 mg of midazolam, 30 - 60 min prior to the induction of anesthesia.
3. Let the patient be monitored according to standard guidelines, with direct arterial and central venous pressure access by the anesthesiologists. Induce anesthesia using an initial intravenous injection of 0.5 - 1.5 mg/kg propofol, 1 - 2 µg/kg fentanyl, and 0.6 mg/kg rocuronium.
4. Perform tracheal intubation and maintain the anesthesia through the intravenous infusion of 100 - 150 µg/kg/min propofol, 0.015 - 0.03 µg/kg/min fentanyl, and 0.6 - 1.2 µg/kg/min rocuronium as needed.
5. Install the patient in a supine position and drape her/him in a sterile fashion, leaving the chest, the abdomen, and the groin free in the operative field.

2. Surgery

1. To minimize crowding of the operative field by cannulas, establish the cardio-pulmonary bypass access outside the thorax.
   1. Perform a 6 cm-long incision 2 cm below and parallel to the right clavicle. Prepare the right subclavian artery, freeing it from the surrounding tissue. Give 300 I.U. of heparin/kg through the IV line.
   2. Side-clamp the right subclavian artery with a Cooley Derra clamp. Perform a 10 mm-long arteriotomy of the vessel parallel to its axis.
   3. Sew an 8-mm Dacron graft end-to-end to the arteriotomy using a running 6/0 polypropylene monofilament suture (e.g., Prolene). Cannulate the graft with a 24 Fr elongated one-piece arterial cannula for arterial return to the patient.
   4. Under transesophageal echocardiographic guidance, cannulate the right femoral vein percutaneously over a guidewire for venous drainage.
2. Access the heart through a median sternotomy.
   1. Incise the skin longitudinally over 15 cm, starting 1 cm below the suprasternal notch. Take care to stay in the middle of the sternal width.
   2. Saw the sternum with an oscillatory saw. Take care to stay in the middle of the sternal width.
   3. Incise the pericardium over the aorta to uncover the massively dilated and tortuous right coronary artery.
      1. Grab the pericardium with Carpentier dissection forceps. Cut the pericardium with Metzenbaum scissors. Continue cutting the pericardium up to its reflection line over the ascending aorta using electrocautery.
   4. Start the extra-corporeal circulation and dissect the aorta circumferentially, freeing it from the surrounding tissue, including the pulmonary artery, taking care not to injure the anomalous left coronary artery.
      1. Gently push the ascending aorta to the left using a lung retractor. Grab the soft tissue behind the ascending aorta with Carpentier dissection forceps.
      2. Separate the posterior wall of the ascending aorta from the surrounding tissue using electrocautery. Continue caudally behind the ascending aorta. Make sure not to injure the right pulmonary artery behind the ascending aorta.
      3. Grab the main pulmonary artery with Carpentier dissection forceps and push it gently towards the left side. Separate the left lateral wall of the ascending aorta from the main pulmonary artery using electrocautery.
   5. Dissect the main pulmonary artery free from the surrounding tissue.
      1. Pull the ascending aorta towards the right side using a peanut gauze mounted on an Allis clamp.
      2. Bluntly dissect the posterior wall of the main pulmonary artery with a second peanut gauze mounted on an Allis clamp. Make sure not to injure the main left coronary artery behind the main pulmonary artery.
      3. Pass a dissector under the main pulmonary artery. Gently open the dissector to prepare a tunnel for the passage of the vessel loop.
      4. Bring down a vessel loop mounted on Carpentier dissection forceps and place it between the open jaws of the dissector. Close the jaws of the dissector to grab the vessel loop.
      5. Grab the adventitia of the ascending aorta and pull the vessel loop held by the dissector to encircle the main pulmonary artery.
   6. Place a left ventricular vent.
      1. Place a purse-string on the right upper pulmonary vein with a 4/0 polypropylene monofilament suture.
      2. Gently push the superior vena cava towards the left side.
      3. Make a small cut in the middle of the purse-string on the right upper pulmonary vein with an 18-blade knife (see the Materials List).
      4. Gently dilate the opening with a Leriche hemostatic clamp.
      5. Insert a vent through the right upper pulmonary vein and the mitral valve into the left ventricle to unload the left heart. Secure it with a braided polyester 2/0 ligature with polybutylene coating.
   7. Place a retrograde cardioplegic cannula through the coronary sinus. Secure it with a braided polyester 2/0 ligature with a polybutylene coating.
   8. Install the antegrade cardioplegic root.
      1. Place a purse-string on the main pulmonary artery with a 4/0 polypropylene monofilament suture.
      2. Make a small cut in the middle of the purse-string on the main pulmonary artery with an 18-blade knife (see the Materials List).
      3. Gently dilate the opening with a Leriche hemostatic clamp. Insert an antegrade cardioplegic cannula in the main pulmonary artery. Secure it with a braided polyester 2/0 ligature with polybutylene coating.
      4. Place a purse-string on the ascending aorta with a 4/0 polypropylene monofilament suture.
      5. Make a small cut in the middle of the purse-string on the ascending aorta with an 18-blade knife.
      6. Gently dilate the opening with a Leriche hemostatic clamp.
      7. Insert an antegrade cardioplegic cannula into the ascending aorta. Secure it with a braided polyester 2/0 ligature with polybutylene coating. Cut the ligature with Metzenbaum scissors. Verify the correct placement of the antegrade cardioplegic cannulas in the main pulmonary artery and ascending aorta.
3. Prepare to open the aorta.
   1. Cross-clamp the aorta as distally as possible. Deliver the antegrade cold blood cardioplegia simultaneously through the aorta and the pulmonary artery.
   2. Remove the cannulas from the aorta and the pulmonary artery and repeat the cold blood cardioplegia retrogradely every 20 min.
   3. Transect the aorta.
      1. Grab the ascending aorta with Carpentier dissection forceps on each side of the opening left following the removal of the cardioplegic cannula. Enlarge the opening with an 18-blade knife.
      2. Finish the transection of the aorta with Metzenbaum scissors. Verify the absence of the left coronary ostium inside the aorta in the left sinus of Valsalva.
   4. Transect the main pulmonary artery.
      1. Grab the main pulmonary artery with Carpentier dissection forceps on each side of the opening left following the removal of the cardioplegic cannula. Enlarge the opening with an 18-blade knife.
      2. Finish the transection of the main pulmonary artery with Metzenbaum scissors. Confirm the presence of the left coronary ostium, originating from the right-facing sinus 1¹⁰ of the pulmonary artery.
   5. Detach the left coronary ostium from the right-facing sinus 1 of the pulmonary artery.
      1. Grab the proximal main pulmonary artery with Carpentier dissection forceps. Using Metzenbaum scissors, separate the left coronary ostium from the right-facing sinus 1 of the pulmonary artery with a generous surrounding patch of the pulmonary root wall, taking care not to injure the pulmonary valve.
      2. Mobilize the main left coronary artery up to its bifurcation.
4. Prepare for the re-implantation of the left coronary ostium.
   1. Grab the proximal ascending aorta with Carpentier dissection forceps.
   2. Use a straight blade to create a neo-ostium in the left sinus 2 of the aorta. Leave a 10-mm margin of aortic root wall around the neo-ostium towards the commissure between the left sinus 2 and the right coronary sinus of the aorta, as well as towards the aortic annulus.
   3. Connect the main left coronary ostium end-to-end to the neo-ostium in the left sinus 2 of the aorta using a running 6/0 polypropylene monofilament suture. Start the anastomosis at the deepest point of the main left coronary ostium and allow it to come up on the right-hand side of the anastomosis. Complete the anastomosis by running the left-hand side of the suture to meet the other end.
   4. To relieve tension on the tissue when pulling the sutures, bring the aorta and the main left coronary ostium together each time.
5. Repair the defect in the pulmonary artery root.
   1. Use a non-treated autologous pericardial patch.
   2. Connect the autologous pericardial patch at the deepest point of the right-facing sinus 1 of the pulmonary artery using a running 6/0 polypropylene monofilament suture.
   3. First run up the left and then the right end of the suture to mid-height of the defect in the right-facing sinus 1 of the pulmonary artery. Leave the two ends of the suture under tension.
6. Reestablish the continuity of the great vessels.
   1. Reconnect the proximal part of the aorta to its distal part with an end-to-end anastomosis using a running 5/0 polypropylene monofilament suture. Start the anastomosis at the deepest point, allowing it to come up on the right-hand side of the anastomosis. Complete the anastomosis by running the left-hand side of the suture to meet the other end.
   2. De-air the aorta. Remove the aortic cross-clamp. Start rewarming the patient.
   3. To shorten the ischemic time, perform the reconnection of the proximal and distal parts of the pulmonary artery on the beating heart. Put the pump sucker into the distal pulmonary artery to improve the sight of the operative field.
   4. Continue in a running fashion the left end of the 6/0 polypropylene suture that had been stopped at mid-height of the defect in the right-facing sinus 1 of the pulmonary artery to complete the posterior and left aspects of the anastomose.
   5. Continue in a running fashion the right end of the 6/0 polypropylene suture that had been stopped at mid-height of the defect in the right-facing sinus 1 of the pulmonary artery to complete the posterior and right aspects of the anastomose. Tie the two ends of the suture to finish the connection.

Results

Presentation

The patient was a 48-year-old woman presenting with the recent onset of angina Canadian Cardiovascular Society (CCS) grad III and occasional palpitations. She reported three uneventful pregnancies. Moderate smoking was the main cardiovascular risk factor. Trans-thoracic echocardiography showed a moderately impaired (45%) left ventricular ejection fraction and no mitral regurgitation. A coronary angiography was then per...

Discussion

This protocol describes a detailed technique for the direct re-implantation of the ALCAPA into the aorta in an adult patient with the origin of main left coronary artery from the right-facing sinus of the pulmonary artery according to the Dodge-Khatami classification¹⁰. The myocardial protection strategy and the reconstruction of the pulmonary artery are clearly demonstrated. The major critical step of this technique is represented by the generous mobilization of the left coronary artery to achiev...

Materials

List of materials used in this article

Name	Company	Catalog Number	Comments
Heart surgery infrastructure
Heart Lung Machine	Stockert	SIII
EOPA 24Fr. arterial cannula	Medtronic	77624
Quickdraw 25Fr. femoral venous cannula	Edwards	QD25
LV vent catheter 17Fr.	Edwards	E061
Antegrade 9Fr. cardioplegia cannula	Edwards	AR012V
Retrograde 14Fr. cardioplegia cannula	Edwards	NPC014
Electrocautery	Covidien	Force FX
Sutures
Polypropylene 4/0	Ethicon	8871H
Polypropylene 5/0	Ethicon	8870H
Polypropylene 6/0	Ethicon	EH7400H
Braided polyesther 2/0 ligature with polybutylate coating	Ethicon	X305H
Intergard dacron graft 8 mm	Maquet	IGW0008-30
Micro knife Sharpoint	TYCO Healthcare PTY	78-6900
Drugs
Midazolam	Roche Pharma	N05CD08
Rocuronium	MSD Merck Sharp & Dohme	M03AC09
Propofol	Fresenius Kabi	N01AX10
Fentanil	Actavis	N01AH01
Instruments
Cooley Derra anastomosis clamp	Delacroix-Chevalier	DC40810-16
Cooley vascular clamp	Delacroix-Chevalier	DC40810-16
Dissection forceps Carpentier	Delacroix-Chevalier	DC13110-28
Scissors Metzenbaum	Delacroix-Chevalier	B351751
Needle holder Ryder	Delacroix-Chevalier	DC51130-20
Dissection forceps DeBakey	Delacroix-Chevalier	DC12000-21
Micro needle holder Jacobson	Delacroix-Chevalier	DC50002-21
Micro scisors Jacobson	Delacroix-Chevalier	DC20057-21
Lung retractor	Delacroix-Chevalier	B803990
Allis clamp	Delacroix-Chevalier	DC45907-25
O’Shaugnessy Dissector	Delacroix-Chevalier	B60650
Vessel loop	Medline	VLMINY
18 blade knife	Delacroix-Chevalier	B130180
Leriche haemostatic clamp	Delacroix-Chevalier	B86555