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Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure
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Direct Analysis of Single Cells by Mass Spectrometry at Atmospheric Pressure

Article DOI: 10.3791/2144-v • 08:19 min • September 4th, 2010
September 4th, 2010 •
1, 1
1Department of Chemistry, George Washington University

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Single cell analysis is performed by mass spectrometry on plant and animal cells at atmospheric pressure by using a sharpened optical fiber to sample the cells for laser ablation electrospray ionization (LAESI) mass spectrometry.

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Single Cells Mass Spectrometry Atmospheric Pressure Biochemical Analysis Cell Metabolism Cell Cycle Adaptation Disease States Heterogeneous Biochemical Makeup Sample Preparation Ambient Ionization Methods Mid Infrared Laser Ablation Water-rich Tissues Biofluids LAESI AP IR-MALDI
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