Here, we present protocols to perform both ambient mass spectrometry imaging (MSI) of tissues and in-situ live single cell MS (SCMS) analysis using the single-probe, which is a miniaturized multifunctional device for MS analysis.
Rao, W., Pan, N., Yang, Z. Applications of the Single-probe: Mass Spectrometry Imaging and Single Cell Analysis under Ambient Conditions. J. Vis. Exp. (112), e53911, doi:10.3791/53911 (2016).