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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
 

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Article doi: 10.3791/56714
December 28th, 2017

Summary December 28th, 2017

This study implemented whole genome sequencing for analysis of mutations in genes conferring antifungal drug resistance in Candida glabrata. C. glabrata isolates resistant to echinocandins, azoles and 5-flucytosine, were sequenced to illustrate the methodology. Susceptibility profiles of the isolates correlated with presence or absence of specific mutation patterns in genes.

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