Waiting
Login processing...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Medicine / Microarray-based Identification of Individual…
JoVE Journal
Medicine

This content is Open Access.

JoVE Journal Medicine
Microarray-based Identification of Individual HERV Loci Expression
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Journal (Medicine)
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Vacuuming and Pouring of the Phantom Material Samples into the Mold
Journal (Medicine)
Vacuuming and Pouring of the Phantom Material Samples into the Mold
 

Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

Article DOI: 10.3791/50713 • 13:19 min • November 2nd, 2013
November 2nd, 2013 •
1,2, 1,2, 1,3,4, 1,2, 5, 1,4,6, 1,4,7, 1,2
1Joint Unit Hospices de Lyon-bioMérieux, 2Medical Diagnostic Discovery Department, BioMérieux, 3Department of Pathology and Cytology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 4Medical Faculty, Lyon 1 University, 5Data and Knowledge Laboratory, BioMérieux, 6Department of Biochemistry and Molecular Biology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, 7Department of Urology, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon

Chapters

Summary
Automatic Translation

Human endogenous retroviruses (HERV), which occupy 8% of the human genome, retain scarce coding capacities but a hundred thousand long terminal repeats (LTRs). A custom Affymetrix microarray was designed to identify individual HERV locus expression and was used on prostate cancer tissues as a proof of concept for future clinical studies.

Tags

Microarray HERV Loci Expression Biomarker Discovery Prostate Cancer PSA Diagnostic Biomarker Specificity Sensitivity Low Dosage Values Gray Zone Noncoding RNAs NcRNAs PCA3 ENCODE Project Transcriptional Regulatory Motifs Long Terminal Repeats (LTRs) Human Endogenous Retroviruses (HERVs)
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter