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JoVE Journal
Immunology and Infection

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在小鼠B淋巴细胞染色体畸变所PNA-FISH快速分析
 
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在小鼠B淋巴细胞染色体畸变所PNA-FISH快速分析

Article DOI: 10.3791/51806
August 19th, 2014

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Summary August 19th, 2014

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DNA修复途径对于维持基因组的完整性,防止基因突变和癌症至关重要。该协议的目的是通过直接观察染色体畸变的量化基因组不稳定性在中期从原位杂交(FISH)对端粒DNA重复使用荧光小鼠B细胞的扩散。

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