This content is Free Access.
Chapters
- 00:05Title
- 01:07Intra-articular Injection of Monoiodoacetate (MIA) in the Knee
- 03:57Measurement of Mechanical Hypersensitivity (Allodynia)
- 06:00Measurement of Weight Bearing Deficit
- 07:29Results: Behavioral Changes after MIA Injection
- 08:22Conclusion
Osteoarthritis (OA), or degenerative joint disease, is a debilitating condition associated with pain that remains only partially controlled by available analgesics. Animal models are being developed to improve our understanding of OA-related pain mechanisms. Here we describe the methodology for the monoiodoacetate model of OA pain in the mouse.
Tags
Monoiodoacetate ModelOsteoarthritis PainMouse Knee JointIntra-articular InjectionMechanical SensitivityWeight Bearing DeficitsPain MechanismsPharmacological TargetsTherapy DevelopmentMIA Dose AdjustmentConstant Pain ResponsesPain Relieving TherapiesDrug DiscoveryExperimental SetupRandomizationBlind ExperimenterMIA Solution Preparation
