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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
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JoVE Journal Medicine
The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

DOI:
10.3791/51608-v

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07:09 min

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July 16, 2014

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, , , , , ,
1Institut des Neurosciences Cellulaires et Intégratives UPR3212,Centre National de la Recherche Scientifique, 2Université de Strasbourg, 3Hôpitaux Universitaires de Strasbourg

Chapters

  • 00:05Title
  • 01:27Measuring Paw Withdrawal: Von Frey Test
  • 03:20Cuff Implantation Surgery
  • 05:51Drug Treatments and Pain Responses
  • 06:37Conclusion

Summary

Automatic Translation

Automatic Translation

Neuropathic pain is a consequence of a lesion or disease affecting the somatosensory system. The “cuff model” of neuropathic pain in mice consists of the implantation of a polyethylene cuff around the main branch of the sciatic nerve. Mechanical allodynia is tested using von Frey filaments.

Tags

Keywords: Sciatic NerveNeuropathic PainMurine ModelPeripheral Nerve InjuryCuff ModelMechanical AllodyniaVon Frey FilamentsSomatosensory SystemNociceptive PathwayCentral Nervous SystemChronic PainTreatment

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