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JoVE Journal
Medicine

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The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice
 

The Sciatic Nerve Cuffing Model of Neuropathic Pain in Mice

Article DOI: 10.3791/51608
July 16th, 2014

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Summary July 16th, 2014

Neuropathic pain is a consequence of a lesion or disease affecting the somatosensory system. The “cuff model” of neuropathic pain in mice consists of the implantation of a polyethylene cuff around the main branch of the sciatic nerve. Mechanical allodynia is tested using von Frey filaments.

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