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Intraluminal Drug Delivery to the Mouse Arteriovenous Fistula Endothelium

Article DOI: 10.3791/53905-v • 05:53 min • March 4th, 2016
March 4th, 2016 •
1,2,3, 1,2,3, 1, 1, 4, 1,3
1Department of Surgery and the Vascular Biology and Therapeutics Program, Yale University, 2Department of Vascular Surgery, University of Tokyo, 3Department of Vascular Surgery, VA Connecticut Healthcare Systems, 4Department of Vascular Surgery, International University of Health and Welfare Mita Hospital

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Summary
Automatic Translation

After puncturing the aorta through the inferior vena cava (IVC) to create an aorto-caval fistula in the mouse, solution containing a drug is infused into the IVC via the same needle, followed by incubation. This method enables more robust drug delivery to the venous endothelium compared to the external route.

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Intraluminal Drug Delivery Mouse Arteriovenous Fistula Endothelium AVF Model Drug Delivery Method Endothelial Role In Venous Remodeling Neointimal Hyperplasia Single Needle Technique Surgical Instruments Vascular Clamps One-milliliter Syringe 25 Gauge Needle Drug Administration Curved Needle Holder C57 Black 6 Mouse Abdominal Incision Retractor Bowels Displacement Retroperitoneum Dissection Aorta And IVC Preparation
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