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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

DOI:
10.3791/56564-v

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09:52 min

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March 16, 2018

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, , , ,
1Department of Surgery, Division of Otolaryngology,Southern Illinois University School of Medicine, 2Department of Pharmacology,Southern Illinois University School of Medicine

Chapters

  • 00:04Title
  • 00:57Auditory Brainstem Response (ABR)
  • 01:59Trans-tympanic Injection
  • 03:55Cochlea Dissection and Decalcification
  • 04:38Cryosectioning and Immunohistochemistry
  • 07:37Results: Representative Effects of Trans-tympanic Drug/Biologic Delivery to the Rat Cochlea
  • 09:20Conclusion

Summary

Automatic Translation

Automatic Translation

We present a technique for localized administration of drugs through the trans-tympanic route into the cochlea. Drug delivery through this route would not interfere with the anti-cancer efficacy of the chemotherapeutic drugs such as cisplatin.

Tags

Keywords: Trans-tympanicDrug DeliveryOtotoxicityAntioxidantsOtoprotective AgentsBiological ReagentsCochleaHearing LossCisplatinAuditory Brainstem ResponseHigh-frequency TransducersTympanic MembraneInsulin Syringe

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