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重复性的动脉剥脱损伤腹主动脉阻断在小鼠模型

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JoVE Journal Medicine

Reproducible Arterial Denudation Injury by Infrarenal Abdominal Aortic Clamping in a Murine Model

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重复性的动脉剥脱损伤腹主动脉阻断在小鼠模型

DOI:

10.3791/54755-v

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08:33 min

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November 24, 2016

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Aditya S. Shirali, Austin I. McDonald, Julia J. Mack, M. Luisa Iruela-Arispe

¹Department of Surgery,University of California, Los Angeles, ²Molecular Biology Institute,University of California, Los Angeles, ³Department of Molecular, Cell, and Developmental Biology,University of California, Los Angeles

Chapters

00:05Title
01:14Infrarenal Aortic Clamping
03:59Closure of Laparotomy and Postoperative Assessment
04:58Aortic Dissection and Staining
05:40Results: Efficiency of Endothelial Denudation and Reproducibility and Denudation Injury
07:28Conclusion

Summary

Automatic Translation

理解再内皮的细胞和分子机制下列动脉剥蚀损伤是至关重要的在防止血栓形成和动脉的再狭窄。在这里，我们描述了肾腹主动脉动脉可重复性损伤剥蚀的协议。该程序的开发研究，规范使用小鼠模型内皮细胞再生的基本机制。

Tags

Arterial Denudation Aortic Clamping Murine Model Vascular Biology Endothelial Regeneration Endothelial Cell Progenitors Vascular Injury Re-endothelialization Thrombotic Events Stent Deployment Coronary Artery Disease Peripheral Vascular Disease Surgical Procedure Anesthesia Abdominal Incision Intestine Retraction Retroperitoneal Dissection Aortic Exposure

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