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Longitudinal In Vivo Imaging of the Cerebrovasculature

Longitudinal In Vivo Imaging of the Cerebrovasculature: Relevance to CNS Diseases

Article DOI: 10.3791/54796
December 6th, 2016


Summary December 6th, 2016

This manuscript describes a procedure to track the remodeling of the cerebrovasculature during amyloid plaque accumulation in vivo using longitudinal two-photon microscopy. A thinned-skull preparation enables the visualization of fluorescent dyes to assess the progression of cerebrovascular damage in a mouse model of Alzheimer's disease.


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