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Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
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Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle

DOI:
10.3791/54977-v

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09:40 min

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January 19, 2017

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, , , , , ,
1Davis Heart and Lung Research Institute,The Ohio State University, 2Laboratory of Clinical Investigation,National Institute on Aging, 3Division of Endocrinology, Diabetes and Metabolism,The Ohio State University, 4Department of Human Sciences, Human Nutrition,The Ohio State University, 5Division of Endocrinology and Diabetes, Department of Pediatrics,University of Pennsylvania

Chapters

  • 00:05Title
  • 01:09Preparation and Subject Positioning
  • 03:25Scanning Protocol
  • 05:47Baseline Exercise and Post-exercise Acquisition
  • 07:08Results: Phosphors-31 Magnetic Resonance Spectroscopy
  • 08:24Conclusion

Summary

Automatic Translation

Automatic Translation

This work demonstrates the feasibility of an in vivo phosphorus-31 magnetic resonance spectroscopy (31PMRS) technique to quantify mitochondrial oxidative phosphorylation (OXPHOS) capacity in human skeletal muscle.

Tags

Keywords: Phosphorus-31 Magnetic Resonance SpectroscopyIn VivoMitochondrial Oxidative PhosphorylationSkeletal MuscleNoninvasive MeasurementExercise ProtocolTargeted TherapiesMRICoil PositioningSubject Positioning

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