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JoVE Journal
Immunology and Infection

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Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells
 

Dextran Enhances the Lentiviral Transduction Efficiency of Murine and Human Primary NK Cells

Article doi: 10.3791/55063
January 15th, 2018

Summary January 15th, 2018

The goal of this study was to formulate technologies that allow for successful gene transduction in primary natural killer (NK) cells. The dextran-mediated lentiviral transduction of human or mouse primary NK cells results in higher gene expression efficiencies. This method of gene transduction will vastly improve NK cell genetic manipulation.

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