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Ultraljud-guidad intrakardiellt injektion av humana mesenkymala stamceller att öka Homing till tarmen för användning i murina modeller av experimentella inflammatoriska tarmsjukdomar
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Ultraljud-guidad intrakardiellt injektion av humana mesenkymala stamceller att öka Homing till tarmen för användning i murina modeller av experimentella inflammatoriska tarmsjukdomar

Article DOI: 10.3791/55367-v • 07:46 min • September 1st, 2017
September 1st, 2017 •
1, 1, 2,3, 5, 4, 2,3, 5, 1
1Division of Gastroenterology and Liver Disease, University Hospitals, Digestive Health Research Institute, Case Western Reserve University, 2Case Cardiovascular Research Institute, School of Medicine, Case Western Reserve University, 3Department of Medicine, Harrington Discovery Institute, Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, 4Department of Radiology, University Hospitals Case Medical Center, 5Department of Biology - Skeletal Research Center, Case Western Reserve University

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Murina studier i modeller av kolon inflammation har visat att en liten andel (1-5%) av mesenkymala stamceller (MSC) injiceras intravenöst eller intraperitonealt hem till den inflammera kolon1,2. Denna studie visar att ultraljud-guidad intrakardiellt injektioner av MSCs resultera i ökad lokalisering till tarmen.

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Medicin fråga 127 mesenkymala stamceller (MSC) Crohns sjukdom SAMP1/YitFc ultraljud-guidad intrakardiellt injektion hMSC transduktion Mareld imaging
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