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自动 Dicentric 染色体识别 (ADCI) 和剂量估计加速辐射剂量

JoVE Journal
Genetics

This content is Free Access.

JoVE Journal Genetics

Expedited Radiation Biodosimetry by Automated Dicentric Chromosome Identification (ADCI) and Dose Estimation

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自动 Dicentric 染色体识别 (ADCI) 和剂量估计加速辐射剂量

DOI:

10.3791/56245-v

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10:33 min

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September 04, 2017

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Ben Shirley*¹, Yanxin Li*¹, Joan H.M. Knoll², Peter K. Rogan³

¹CytoGnomix Inc., ²Department of Pathology and Laboratory Medicine,Western University, ³Department of Biochemistry,Western University

Chapters

00:05Title
01:28Preparing Blood Cell Image Sample Sets for Automated Analysis by Software to Automate Dicentric Chromosome Detection and Estimate Radiation Exposure
03:32Analyzing the Prepared Samples
05:00Dose Estimation and Reports
07:24Results: Testing the Software
09:18Conclusion

Summary

Automatic Translation

细胞遗传学 dicentric 染色体 (DC) 检测量化暴露于电离辐射。自动 Dicentric 染色体标识符和剂量估计软件准确快速地估计了中期细胞中 DCs 的生物剂量。它区别 monocentric 染色体和其他对象从 dcs, 并且估计生物辐射剂量从 dcs 的频率。

Tags

Radiation Biodosimetry Dicentric Chromosome Identification Automated Image Processing Radiation Dose Estimation Machine Learning Cytogenetic Analysis Metaphase Chromosome Images Radiation Exposure Calibration Curve Sample Processing Image Filtering Genetic Disease Diagnosis

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