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JoVE Journal
Immunology and Infection

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Stenosis of the Inferior Vena Cava

Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis

Article DOI: 10.3791/56697 05:37 min December 22nd, 2017
December 22nd, 2017



We describe here stenosis in the inferior vena cava as a murine model of deep vein thrombosis. This model recapitulates blood flow restriction, one of the major triggers of venous thrombosis in humans.



Stenosis Inferior Vena Cava Murine Model Deep Vein Thrombosis Surgical Procedure Blood Flow Distortion Mechanisms Thrombosis Initiation Advantage Simulates Blood Flow Disturbance Visual Demonstration Shaving Anesthetized Mouse Supine Position Heating Pad Disinfect Sedation Level Confirmation Sterile Drape Surgical Site Incision Abdominal Midline Cotton Buds Exteriorize Intestines Sterile Gauze Saline Solution
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