Summary
September 13th, 2018
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Hier presenteren we een gestandaardiseerd protocol voor het meten van de nasale potentiaalverschil (NPD). Cystic fibrosis transmembrane huidgeleiding regelgever (CFTR) en epitheliale natrium kanaal (ENaC) functie worden geëvalueerd door de verandering in de spanning over de nasale epitheel na superfusion van oplossingen die ion kanaal activiteit, wijzigen mits een resultaat maatregel.
Transcript
This method can help answer key questions in the CF and ion transport fields about whether CF patients can mount a meaningful response to activation or restoration of CFTR function.The main advantage of this technique is that it measures the coordinated activity of the CFTR and epithelial sodium channel in the airway epithelium.Although this method can provide insight into cystic fibrosis, it can also be applied to other disease systems, such as genetic disorders of hyperactive epithelial sodium channel function.Demonstrating the procedure will be Thao Nguyen, biologist, and Aur