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JoVE Journal
Biochemistry

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酶活化致癌物和药物对共价 DNA 加合物的生成研究体外及其32 P-postlabeling 的测定
 
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酶活化致癌物和药物对共价 DNA 加合物的生成研究体外及其32 P-postlabeling 的测定

Article DOI: 10.3791/57177
March 20th, 2018

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Summary March 20th, 2018

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评价环境化学物质和药物的效力, 将其酶 bioactivated 到产生共价 DNA 加合物的中间体, 是癌症及其治疗发展的一个重要领域。方法描述了复合活化形成 DNA 加合物, 以及检测和定量的技术。

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