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Neuroscience

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JoVE Journal Neuroscience
Råtta modell av utbredd cerebrala när demyelination framkallas av en intrakraniell injektion av proinflammatoriska cytokiner
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Råtta modell av utbredd cerebrala när demyelination framkallas av en intrakraniell injektion av proinflammatoriska cytokiner

Article DOI: 10.3791/57879-v • 09:46 min • September 21st, 2021
September 21st, 2021 •
*1, *2, 3, 4, 1, 2, 2
1Research Unit of Experimental Neurotraumatology, Department of Neurosurgery, Medical University Graz, 2Department of Neurology, Medical University Graz, 3Centre for Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, 4Division of Vascular Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet
* These authors contributed equally

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Protokollet som presenteras här tillåter reproduktion av en utbredd grå materia demyelination av båda när halvklot i vuxna manliga Dark Agouti råttor. Metoden består av intracerebral implantation av en kateter, subklinisk immunisering mot myelin oligodendrocyte glykoprotein och intracerebral injektion av en proinflammatorisk cytokinblandning genom implanterad kateter.

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Återkallelse utgåva 175 När demyelination multipel skleros djurmodell progressiv multipel skleros neuroinflammation demyeliniserande sjukdomar
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