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Lipidomics og transcriptomics i neurologiske sygdomme
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Lipidomics og transcriptomics i neurologiske sygdomme

Article DOI: 10.3791/59423-v • 09:58 min • March 18th, 2022
March 18th, 2022 •
1, 1, 1, 1, 1, 1
1Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz

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Denne artikel præsenterer en modulær protokol for vævlipidomik og transkriptomik og plasmalipidomik i neurologiske sygdomsmusmodeller rettet mod lipider, der ligger til grund for inflammation og neuronal aktivitet, membranlipider, nedstrøms budbringere og mRNA-kodende enzymer / receptorer, der ligger til grund for lipidfunktionen. Prøveudtagnings-, prøvebehandlings-, ekstraktions- og kvantificeringsprocedurer er skitseret.

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Neurovidenskab udgave 181 lipidomics transkriptomik hjerneområder dyremodeller af neurologiske sygdomme hjernens høje rumlige opløsning kvantitativ lipidomik
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