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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Microwave-Assisted Preparation of 1-Aryl-1<em>H</em>-pyrazole-5-amines
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

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05:07 min

June 23, 2019

DOI:

05:07 min
June 23, 2019

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Summary

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1-Aryl-1H-pyrazole-5-amines are prepared from aryl hydrazines combined with either 3-aminocrotononitrile or an α-cyanoketone in a 1 M HCl solution using a microwave reactor. Most reactions are done in 10-15 minutes and pure product can be obtained via vacuum filtration with typical isolated yields of 70-90%.

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