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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

DOI:
10.3791/59896-v

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05:07 min

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June 23, 2019

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, , ,
1Department of Chemistry and Biochemistry,California Polytechnic State University

Chapters

  • 00:04Title
  • 00:42Preparation of Reaction Mixture
  • 01:42Heating the Reaction in The Microwave Reactor
  • 02:35Isolation of The Product by Vacuum Filtration
  • 03:52Results: NMR Spectrum
  • 04:25Conclusion

Summary

Automatic Translation

Automatic Translation

1-Aryl-1H-pyrazole-5-amines are prepared from aryl hydrazines combined with either 3-aminocrotononitrile or an α-cyanoketone in a 1 M HCl solution using a microwave reactor. Most reactions are done in 10-15 minutes and pure product can be obtained via vacuum filtration with typical isolated yields of 70-90%.

Tags

Keywords: 1-Aryl-1H-pyrazole-5-aminesMicrowave-assisted SynthesisAryl Hydrazines3-AminocrotononitrileAlpha CyanoketonesRapid Reaction TimeFunctional Group ToleranceMicrowave VileHeterogeneous SuspensionHydrochloric AcidSodium HydroxideVacuum Filtration

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