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June 23, 2019
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Summary
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1-Aryl-1H-pyrazole-5-amines are prepared from aryl hydrazines combined with either 3-aminocrotononitrile or an α-cyanoketone in a 1 M HCl solution using a microwave reactor. Most reactions are done in 10-15 minutes and pure product can be obtained via vacuum filtration with typical isolated yields of 70-90%.
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Cite this Article
Law, J., Manjunath, A., Schioldager, R., Eagon, S. Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines. J. Vis. Exp. (148), e59896, doi:10.3791/59896 (2019).
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