Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Enas  N. Yousef; Ramakrishna Sesham; Jacob  W. McCabe; Rajpal Vangala; Laurence A. Angel

doi:10.3791/60102

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Ion Mobility-Mass massespektrometri teknikker for fastsettelse av struktur og mekanismer for metal ion Recognition og Redox aktivitet av metall bindende Oligopeptides

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

JoVE Journal
Chemistry

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JoVE Journal Chemistry

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Ion Mobility-Mass massespektrometri teknikker for fastsettelse av struktur og mekanismer for metal ion Recognition og Redox aktivitet av metall bindende Oligopeptides

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9,218 Views

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11:04 min

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September 07, 2019

DOI:

10.3791/60102-v

DOI:

10.3791/60102-v

•

11:04 min

September 07, 2019

•

9195 Views

Enas N. Yousef¹, Ramakrishna Sesham¹, Jacob W. McCabe¹, Rajpal Vangala¹, Laurence A. Angel¹

¹Department of Chemistry,Texas A&M University-Commerce

Summary

Ion mobilitet-masse massespektrometri og molekylære modellering teknikker kan karakterisere selektiv metall chelaterande ytelse av designet metall-binding peptider og kobber-binding peptid methanobactin. Utvikling av nye klasser av metall chelaterande peptider vil bidra til legemidler for sykdommer forbundet med metall ion misbalance.