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JoVE Journal Chemistry
Solid Phase 11C-metylering, rensing og formulering for produksjon av pet Bevegelsesuskarphet
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Solid Phase 11C-metylering, rensing og formulering for produksjon av pet Bevegelsesuskarphet

Article DOI: 10.3791/60237-v • 09:25 min • October 24th, 2019
October 24th, 2019 •
*1, *1, 1, 1, 1, 1,2
1McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 2Department of Neurology and Neurosurgery, McGill University
* These authors contributed equally

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Vi rapporterer en effektiv karbon-11 radiolabeling teknikk for å produsere klinisk relevante Bevegelsesuskarphet for positron emisjon tomografi (PET) ved hjelp av solid fase utvinnings kassetter. 11 flere C-methylating agent sendes gjennom en patron forhåndslastet med forløper og suksessive eluering med vandig etanol gir kjemisk og radiochemically ren PET Bevegelsesuskarphet i høy radio kjemisk gir.

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Kjemi Carbon-11 radiolabeling positron emisjon tomografi Imaging [11c] PiB [11c] ABP688 11C-metylering solid fase støttet syntese solid fase ekstraksjon automatisering
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