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Medicine
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氯乙烯和高脂肪饮食作为环境与肥胖相互作用的典范
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal
Medicine
Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction
Please note that all translations are automatically generated.
Click here for the English version.
氯乙烯和高脂肪饮食作为环境与肥胖相互作用的典范
DOI:
10.3791/60351-v
•
09:15 min
•
January 12, 2020
•
Anna L. Lang
2
,
William T. Goldsmith
4
,
Regina D. Schnegelberger
6
,
Gavin E. Arteel
7
,
Juliane I. Beier
7
1
Department of Pharmacology and Toxicology
,
University of Louisville
,
2
Hepatobiology and Toxicology Program
,
University of Louisville
,
3
Department of Physiology and Pharmacology
,
West Virginia University
,
4
Center for Inhalation Toxicology
,
West Virginia University
,
5
Department of Pharmacology and Chemical Biology
,
University of Pittsburgh
,
6
Pittsburgh Liver Research Center
,
University of Pittsburgh
,
7
Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition
,
University of Pittsburgh
Chapters
00:04
Title
00:42
Experimental Setup and Purified Experimental Diet Acclimatization
01:21
Vinyl Chloride (VC) Inhalation Exposure System Setup
02:17
Pre-Exposure Setup
03:21
Exposure Experiment and VC Concentration Validation
06:12
Post-Exposure
07:01
Results: Representative Effects of VC on the Enhancement of Diet-Induced Liver Injury
08:29
Conclusion
Summary
Automatic Translation
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Automatic Translation
该协议的目标是开发一种低水平毒性暴露的鼠模型,不会造成公开肝损伤,反而会加剧先前存在的肝损伤。这种模式更好地概括了人类接触和接触被认为是安全的毒物浓度时发生的微妙变化。
Tags
Vinyl Chloride
High-fat Diet
Liver Damage
Environment
Obesity
Inhalation Exposure
Animal Model
Chronic Exposure
Safety Assessment
Dietary Effects
Environmental Factors
Metabolic Health
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