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Chemistry
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信息承载Peptoids及其序列定向动态共价自组装的合成
JoVE Journal
Chemistry
This content is Free Access.
JoVE Journal
Chemistry
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
Please note that all translations are automatically generated.
Click here for the English version.
信息承载Peptoids及其序列定向动态共价自组装的合成
DOI:
10.3791/60442-v
•
09:34 min
•
February 06, 2020
•
Samuel C. Leguizamon
,
Abdulla F. Alqubati
,
Timothy F. Scott
3
1
Department of Chemical Engineering
,
University of Michigan
,
2
Department of Chemical Engineering
,
Monash University
,
3
Department of Materials Science and Engineering
,
Monash University
Chapters
00:05
Introduction
01:20
Solid-phase Submonomer Synthesis of Oligo(peptoids)
06:01
Sequence-selective Ladder Self-assembly Through Dissociation/Extraction/Annealing
07:22
Results: Analysis of Information-bearing Peptoids and Their Sequence-directed Dynamic Covalent Self-assembly
08:31
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
提出了一种方案,用于合成信息编码的肽寡聚物,以及将这些肽的序列定向自组装成分子阶梯,使用胺和醛作为动态共价反应物对和刘易斯酸性稀土金属三重膨胀作为多功能试剂。
Tags
Peptoids
Dynamic Covalent Self-assembly
Sequence-directed Assembly
Information-directed Assembly
Lewis Acid
Kinetic Trapping
Covalent Bond Rearrangement
FMOC Photolabile Solid Support Resin
Automated Peptide Synthesizer
Primary Amine
Bromoacetic Acid
DIC
Acetic Anhydride
DMF
NMP
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