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En modifisert to nyre en klipp mus modell av renin regulering i nyrearterie stenose
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En modifisert to nyre en klipp mus modell av renin regulering i nyrearterie stenose

Article DOI: 10.3791/61058-v • 08:21 min • October 26th, 2020
October 26th, 2020 •
1, 1, 1, 1
1Department of Medicine/Clinical Pharmacology Division, Vanderbilt University Medical Center

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En modifisert 2 nyre 1 klipp (2K1C) Goldblatt musemodell ble utviklet ved hjelp av polyuretanrør for å initiere nyrearteriestenose, noe som induserte en økning i reninuttrykk og nyreskade. Her beskriver vi en detaljert prosedyre for å forberede og plassere mansjetten på nyrearterien for å generere en reproduserbar og konsistent 2K1C musemodell.

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Medisin To nyre en klipp (2K1C) Nyrearterie stenose Renin Angiotensin Aldosterone System renin uttrykk Nyreskade mus modell
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