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JoVE Journal Cancer Research
Ortotopisk transplantasjon av brystsvulster som prekliniske modeller for brystkreft
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Ortotopisk transplantasjon av brystsvulster som prekliniske modeller for brystkreft

Article DOI: 10.3791/61173-v • 07:45 min • May 18th, 2020
May 18th, 2020 •
*1,2,3, *1,2,3, 1,2,3, 1,2,3, 1,2,3, 1,2,3
1Department of Molecular and Cellular Biology, Baylor College of Medicine, 2Lester and Sue Smith Breast Center, Baylor College of Medicine, 3Dan L. Duncan Cancer Center, Baylor College of Medicine
* These authors contributed equally

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Pasientavledede xenograftmodeller (PDX) og transplanterbare genetisk konstruerte musemodeller rekapitulerer trofast menneskelig sykdom og er foretrukne modeller for grunnleggende og translasjonell brystkreftforskning. Her beskrives en metode for å ortopisk transplantere brystsvulstfragmenter i brystfettputen for å studere tumorbiologi og evaluere legemiddelrespons.

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Kreftforskning Utgave 159 brystkreft preklinisk modell mammary fettputetransplantasjon tumorbiologi legemiddelrespons biomarkør
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