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JoVE Journal Neuroscience
Levering af antistoffer i hjernen ved hjælp af fokuseret scanning ultralyd
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Levering af antistoffer i hjernen ved hjælp af fokuseret scanning ultralyd

Article DOI: 10.3791/61372-v • 07:34 min • July 18th, 2020
July 18th, 2020 •
1, 1, 1, 1, 1
1Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland

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Præsenteret her er en protokol til forbigående at åbne blod-hjerne-barrieren (BBB) enten fokalt eller i hele en musehjerne for at levere fluorescerende mærkede antistoffer og aktivere microglia. Også præsenteret er en metode til at detektere levering af antistoffer og mikroglia aktivering ved histologi.

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Neurovidenskab udgave 161 fokuseret ultralyd scanning ultralyd antistoffer neurovidenskab microglia Alzheimers sygdom lægemiddellevering
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