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JoVE Journal Neuroscience
Bruk av optogenetikk for å reversere nevroplastisitet og hemme kokainsøking hos rotter
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Bruk av optogenetikk for å reversere nevroplastisitet og hemme kokainsøking hos rotter

Article DOI: 10.3791/63185-v • 09:43 min • October 5th, 2021
October 5th, 2021 •
1,2, 1, 1
1Department of Psychiatry, University of Pittsburgh, 2Department of Psychiatry, Rutgers University

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Metodene beskrevet her skisserer en prosedyre som brukes til å optogenetisk reversere kokainindusert plastisitet i en atferdsmessig relevant krets hos rotter. Vedvarende lavfrekvent optisk stimulering av thalamo-amygdala-synapser induserer langvarig depresjon (LTD). In vivo optogenetisk indusert LTD hos kokain-erfarne rotter resulterte i påfølgende demping av signalmotivert narkotikasøking.

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Nevrovitenskap utgave 176 langvarig depresjon gjenoppretting amygdala optogenetikk nevromodulering
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