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JoVE Journal Neuroscience
Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection
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Adult Mouse DRG Explant and Dissociated Cell Models to Investigate Neuroplasticity and Responses to Environmental Insults Including Viral Infection

Article DOI: 10.3791/56757-v • 09:23 min • March 9th, 2018
March 9th, 2018 •
1, 1, 2
1Department of Anatomy, Chicago College of Osteopathic Medicine (CCOM), Midwestern University, 2Department of Microbiology and Immunology, Chicago College of Osteopathic Medicine (CCOM), Midwestern University

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Summary
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In this report, the advantages of organotypic cultures and dissociated primary cultures of mouse-derived dorsal root ganglia are highlighted to investigate a wide range of mechanisms associated with neuron-glial interaction, neuroplasticity, neuroinflammation, and response to viral infection.

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Adult Mouse DRG Explant Model Dissociated Cell Model Neuroplasticity Environmental Insults Viral Infection Ex Vivo Model Neuronal Responses Neuroinflammation Pathogens Exposure Dorsal Root Ganglia Explant Primary Dissociated Cell Model Organ-like Complexity Intercellular Microenvironment Cell Cycle Activation Harvesting DRGs Vertebral Column Surgical Mat Spinal Cord
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