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A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats
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Chapters
- 00:05Title
- 00:46Introduction
- 01:25Operant Chambers
- 02:35Habituation and Cocaine Self-Administration (SA) Training
- 04:34Drug-free Period and Extinction of Cocaine-Trained Behavior
- 05:42Reinstatement of Cocaine-Trained Behavior by Footshock Stress
- 07:02Representative Lever-Response Results
- 08:14Conclusion
Animal models of relapse, known as reinstatement procedures, have been used extensively to study the role of stress in relapse to drug seeking. Here, we report on a method for inducing the reinstatement of cocaine seeking in laboratory rats via acute exposures to mild, intermittent electric footshock.
Tags
Footshock-induced ReinstatementCocaine SeekingLaboratory RatsDrug AddictionRelapseAnimal ModelsNeurobiologyPhenomenologyReinstatement ProceduresDrug Self-administration ModelOperant ResponseExtinctionDrug SeekingTraining DrugDrug-associated CuesStressorAcute Non-contingent ExposureEnvironmental StimuliStressMild Intermittent Electric Footshocks
