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An In Vitro Approach to Study Mitochondrial Dysfunction

An In Vitro Approach to Study Mitochondrial Dysfunction: A Cybrid Model

Article DOI: 10.3791/63452-v
March 9th, 2022


Summary March 9th, 2022

Transmitochondrial cybrids are hybrid cells obtained by fusing mitochondrial DNA (mtDNA)-depleted cells (rho0 cells) with cytoplasts (enucleated cells) derived from patients affected by mitochondrial disorders. They allow the determination of the nuclear or mitochondrial origin of the disease, evaluation of biochemical activity, and confirmation of the pathogenetic role of mtDNA-related variants.


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