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辅酶Q过量设置下线粒体通透性转变孔隙的开放概率评估
JoVE Journal
Biology
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JoVE Journal
Biology
Assessment of Open Probability of the Mitochondrial Permeability Transition Pore in the Setting of Coenzyme Q Excess
Please note that all translations are automatically generated.
Click here for the English version.
辅酶Q过量设置下线粒体通透性转变孔隙的开放概率评估
DOI:
10.3791/63646-v
•
07:35 min
•
June 01, 2022
•
Keren K. Griffiths
,
Aili Wang
,
Richard J. Levy
1
Department of Anesthesiology
,
Columbia University Medical Center
Chapters
00:04
Introduction
00:37
Mitochondrial Oxygen Consumption and Membrane Potential (ΔΨ)
05:25
Results: Determination of Voltage Threshold for mPTP Opening in Neonatal Fragile X Syndrome Mice
07:03
Conclusion
Summary
Automatic Translation
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Automatic Translation
该方法利用线粒体通透性转变孔隙对低导质子泄漏的贡献,确定与野生型对照相比,心肌细胞线粒体辅酶Q含量增加的新生儿脆性X综合征小鼠孔隙开放的电压阈值。
Tags
Mitochondrial Permeability Transition Pore
Open Probability
Coenzyme Q
Oxygen Electrode
TPP-selective Electrode
Calibration
Mitochondrial Membrane Potential
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