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直肠类器官形态学分析(ROMA):囊性纤维化的诊断测定
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Article
DOI:
10.3791/63818-v
•
07:56 min
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June 10th, 2022
直肠类器官形态学分析(ROMA):囊性纤维化的诊断测定
June 10th, 2022
•
Senne Cuyx1,2, Anabela S. Ramalho1, Nikky Corthout3,4, Steffen Fieuws5, Eva Fürstová6, Kaline Arnauts7,8, Marc Ferrante7,9, Catherine Verfaillie8, Sebastian Munck3,4, Mieke Boon1,2, Marijke Proesmans1,2, Lieven Dupont10,11, Kris De Boeck1,2, François Vermeulen1,2
1Department of Development and Regeneration, Woman and Child Unit, CF research lab, KU Leuven, 2Department of Pediatrics, Pediatric Pulmonology, University Hospitals Leuven, 3VIB Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, 4Department for Neuroscience, KU Leuven, 5Interuniversity Center for Biostatistics and Statistical Bioinformatics, University of Leuven and University of Hasselt, 6Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 7Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 8Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, 9Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, 10Department of Chronic Diseases, Metabolism and Ageing; Pneumology, KU Leuven, 11Department of Respiratory Diseases, University Hospitals Leuven
Chapters
Summary
Please note that all translations are automatically generated.
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该协议描述了直肠类器官形态学分析(ROMA),这是一种囊性纤维化(CF)的新型诊断测定。形态特征,即圆度(圆度指数,CI)和流明的存在(强度比,IR),是CFTR功能的量度。对189名受试者的分析表明,CF和非CF之间的区别非常明显。