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직장 오가노이드 형태 분석(ROMA)
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Article
DOI:
10.3791/63818-v
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07:56 min
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June 10th, 2022
직장 오가노이드 형태 분석(ROMA): 낭포성 섬유증의 진단 분석
June 10th, 2022
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Senne Cuyx1,2, Anabela S. Ramalho1, Nikky Corthout3,4, Steffen Fieuws5, Eva Fürstová6, Kaline Arnauts7,8, Marc Ferrante7,9, Catherine Verfaillie8, Sebastian Munck3,4, Mieke Boon1,2, Marijke Proesmans1,2, Lieven Dupont10,11, Kris De Boeck1,2, François Vermeulen1,2
1Department of Development and Regeneration, Woman and Child Unit, CF research lab, KU Leuven, 2Department of Pediatrics, Pediatric Pulmonology, University Hospitals Leuven, 3VIB Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, 4Department for Neuroscience, KU Leuven, 5Interuniversity Center for Biostatistics and Statistical Bioinformatics, University of Leuven and University of Hasselt, 6Department of Pediatrics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, 7Department of Chronic Diseases and Metabolism (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, 8Department of Development and Regeneration, Stem Cell Institute Leuven (SCIL), KU Leuven, 9Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, 10Department of Chronic Diseases, Metabolism and Ageing; Pneumology, KU Leuven, 11Department of Respiratory Diseases, University Hospitals Leuven
Chapters
Summary
Please note that all translations are automatically generated.
Click here for the English version.
이 프로토콜은 낭포성 섬유증(CF)에 대한 새로운 진단 분석인 직장 오가노이드 형태 분석(ROMA)을 설명합니다. 형태 학적 특성, 즉 진원도 (원형도 지수, CI)와 루멘의 존재 (강도 비율, IR)는 CFTR 기능의 척도입니다. 189 명의 피험자를 분석 한 결과 CF와 비 CF가 완벽하게 구별되었습니다.